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Peptide-MHC-I from Endogenous Antigen Outnumber Those from Exogenous Antigen, Irrespective of APC Phenotype or Activation

Naïve anti-viral CD8(+) T cells (T(CD8+)) are activated by the presence of peptide-MHC Class I complexes (pMHC-I) on the surface of professional antigen presenting cells (pAPC). Increasing the number of pMHC-I in vivo can increase the number of responding T(CD8+). Antigen can be presented directly o...

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Detalles Bibliográficos
Autores principales:	Sei, Janet J., Haskett, Scott, Kaminsky, Lauren W., Lin, Eugene, Truckenmiller, Mary E., Bellone, Clifford J., Buller, R. Mark, Norbury, Christopher C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479883/ https://www.ncbi.nlm.nih.gov/pubmed/26107264 http://dx.doi.org/10.1371/journal.ppat.1004941

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