Cargando…
Long-term Prognosis of Paroxysmal Atrial Fibrillation and Predictors for Progression to Persistnt or Chronic Atrial Fibrillation in the Korean Population
Little is known about the long-term prognosis of or predictors for the different clinical types of atrial fibrillation (AF) in Korean populations. The aim of this study was to validate a risk stratification to assess the probability of AF progression from paroxysmal AF (PAF) to persistent AF (PeAF)...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479943/ https://www.ncbi.nlm.nih.gov/pubmed/26130952 http://dx.doi.org/10.3346/jkms.2015.30.7.895 |
_version_ | 1782378095563505664 |
---|---|
author | Im, Sung II Chun, Kwang Jin Park, Seung-Jung Park, Kyoung-Min Kim, June Soo On, Young Keun |
author_facet | Im, Sung II Chun, Kwang Jin Park, Seung-Jung Park, Kyoung-Min Kim, June Soo On, Young Keun |
author_sort | Im, Sung II |
collection | PubMed |
description | Little is known about the long-term prognosis of or predictors for the different clinical types of atrial fibrillation (AF) in Korean populations. The aim of this study was to validate a risk stratification to assess the probability of AF progression from paroxysmal AF (PAF) to persistent AF (PeAF) or permanent AF. A total of 434 patients with PAF were consecutively enrolled (mean age; 71.7 ± 10.7 yr, 60.6% male). PeAF was defined as episodes that are sustained > 7 days and not self-terminating, while permanent AF was defined as an ongoing long-term episode. Atrial arrhythmia during follow-up was defined as atrial premature complex, atrial tachycardia, and atrial flutter. During a mean follow-up of 72.7 ± 58.3 months, 168 patients (38.7%) with PAF progressed to PeAF or permanent AF. The mean annual AF progression was 10.7% per year. In univariate analysis, age at diagnosis, body mass index, atrial arrhythmia during follow-up, left ventricular ejection fraction, concentric left ventricular hypertrophy, left atrial diameter (LAD), and severe mitral regurgitation (MR) were significantly associated with AF progression. In multivariate analysis, age at diagnosis (P = 0.009), atrial arrhythmia during follow-up (P = 0.015), LAD (P = 0.002) and MR grade (P = 0.026) were independent risk factors for AF progression. Patients with younger age at diagnosis, atrial arrhythmia during follow-up, larger left atrial chamber size, and severe MR grade are more likely to progress to PeAF or permanent AF, suggesting more intensive medical therapy with close clinical follow-up would be required in those patients. |
format | Online Article Text |
id | pubmed-4479943 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-44799432015-07-01 Long-term Prognosis of Paroxysmal Atrial Fibrillation and Predictors for Progression to Persistnt or Chronic Atrial Fibrillation in the Korean Population Im, Sung II Chun, Kwang Jin Park, Seung-Jung Park, Kyoung-Min Kim, June Soo On, Young Keun J Korean Med Sci Original Article Little is known about the long-term prognosis of or predictors for the different clinical types of atrial fibrillation (AF) in Korean populations. The aim of this study was to validate a risk stratification to assess the probability of AF progression from paroxysmal AF (PAF) to persistent AF (PeAF) or permanent AF. A total of 434 patients with PAF were consecutively enrolled (mean age; 71.7 ± 10.7 yr, 60.6% male). PeAF was defined as episodes that are sustained > 7 days and not self-terminating, while permanent AF was defined as an ongoing long-term episode. Atrial arrhythmia during follow-up was defined as atrial premature complex, atrial tachycardia, and atrial flutter. During a mean follow-up of 72.7 ± 58.3 months, 168 patients (38.7%) with PAF progressed to PeAF or permanent AF. The mean annual AF progression was 10.7% per year. In univariate analysis, age at diagnosis, body mass index, atrial arrhythmia during follow-up, left ventricular ejection fraction, concentric left ventricular hypertrophy, left atrial diameter (LAD), and severe mitral regurgitation (MR) were significantly associated with AF progression. In multivariate analysis, age at diagnosis (P = 0.009), atrial arrhythmia during follow-up (P = 0.015), LAD (P = 0.002) and MR grade (P = 0.026) were independent risk factors for AF progression. Patients with younger age at diagnosis, atrial arrhythmia during follow-up, larger left atrial chamber size, and severe MR grade are more likely to progress to PeAF or permanent AF, suggesting more intensive medical therapy with close clinical follow-up would be required in those patients. The Korean Academy of Medical Sciences 2015-07 2015-06-10 /pmc/articles/PMC4479943/ /pubmed/26130952 http://dx.doi.org/10.3346/jkms.2015.30.7.895 Text en © 2015 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Im, Sung II Chun, Kwang Jin Park, Seung-Jung Park, Kyoung-Min Kim, June Soo On, Young Keun Long-term Prognosis of Paroxysmal Atrial Fibrillation and Predictors for Progression to Persistnt or Chronic Atrial Fibrillation in the Korean Population |
title | Long-term Prognosis of Paroxysmal Atrial Fibrillation and Predictors for Progression to Persistnt or Chronic Atrial Fibrillation in the Korean Population |
title_full | Long-term Prognosis of Paroxysmal Atrial Fibrillation and Predictors for Progression to Persistnt or Chronic Atrial Fibrillation in the Korean Population |
title_fullStr | Long-term Prognosis of Paroxysmal Atrial Fibrillation and Predictors for Progression to Persistnt or Chronic Atrial Fibrillation in the Korean Population |
title_full_unstemmed | Long-term Prognosis of Paroxysmal Atrial Fibrillation and Predictors for Progression to Persistnt or Chronic Atrial Fibrillation in the Korean Population |
title_short | Long-term Prognosis of Paroxysmal Atrial Fibrillation and Predictors for Progression to Persistnt or Chronic Atrial Fibrillation in the Korean Population |
title_sort | long-term prognosis of paroxysmal atrial fibrillation and predictors for progression to persistnt or chronic atrial fibrillation in the korean population |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479943/ https://www.ncbi.nlm.nih.gov/pubmed/26130952 http://dx.doi.org/10.3346/jkms.2015.30.7.895 |
work_keys_str_mv | AT imsungii longtermprognosisofparoxysmalatrialfibrillationandpredictorsforprogressiontopersistntorchronicatrialfibrillationinthekoreanpopulation AT chunkwangjin longtermprognosisofparoxysmalatrialfibrillationandpredictorsforprogressiontopersistntorchronicatrialfibrillationinthekoreanpopulation AT parkseungjung longtermprognosisofparoxysmalatrialfibrillationandpredictorsforprogressiontopersistntorchronicatrialfibrillationinthekoreanpopulation AT parkkyoungmin longtermprognosisofparoxysmalatrialfibrillationandpredictorsforprogressiontopersistntorchronicatrialfibrillationinthekoreanpopulation AT kimjunesoo longtermprognosisofparoxysmalatrialfibrillationandpredictorsforprogressiontopersistntorchronicatrialfibrillationinthekoreanpopulation AT onyoungkeun longtermprognosisofparoxysmalatrialfibrillationandpredictorsforprogressiontopersistntorchronicatrialfibrillationinthekoreanpopulation |