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Lower Levels of Human MOB3B Are Associated with Prostate Cancer Susceptibility and Aggressive Clinicopathological Characteristics
Mps one binder (MOB) proteins are integral components of signaling pathways that control important cellular processes, such as mitotic exit, centrosome duplication, apoptosis, and cell proliferation. However, the biochemical and cellular functions of the human MOB (hMOB) protein family remain largel...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479949/ https://www.ncbi.nlm.nih.gov/pubmed/26130958 http://dx.doi.org/10.3346/jkms.2015.30.7.937 |
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author | Kim, Eun-Ah Kim, Ye-Hwan Kang, Ho Won Yoon, Hyung-Yoon Kim, Won Tae Kim, Yong-June Yun, Seok-Joong Moon, Sung-Kwon Choi, Yung Hyun Kim, Isaac Yi Lee, Sang-Cheol Kim, Wun-Jae |
author_facet | Kim, Eun-Ah Kim, Ye-Hwan Kang, Ho Won Yoon, Hyung-Yoon Kim, Won Tae Kim, Yong-June Yun, Seok-Joong Moon, Sung-Kwon Choi, Yung Hyun Kim, Isaac Yi Lee, Sang-Cheol Kim, Wun-Jae |
author_sort | Kim, Eun-Ah |
collection | PubMed |
description | Mps one binder (MOB) proteins are integral components of signaling pathways that control important cellular processes, such as mitotic exit, centrosome duplication, apoptosis, and cell proliferation. However, the biochemical and cellular functions of the human MOB (hMOB) protein family remain largely unknown. The present study investigated the association between hMOB3B expression and clinicopathological characteristics of prostate cancer (PCa).Study subjects included 137 PCa patients and 137 age-matched benign prostatic hyperplasia (BPH) patients. hMOB3B expression was estimated using real-time PCR and compared with clinicopathological parameters of PCa. hMOB3B mRNA expression was significantly lower in PCa tissues than in BPH control tissues (P<0.001). According to receiver operating characteristics curve analysis, the sensitivity of hMOB3B expression for PCa diagnosis was 84.7%, with a specificity of 86% (AUC=0.910; 95% CI=0.869-0.941; P<0.001). hMOB3B expression was significantly lower in patients with elevated prostate specific antigen (PSA) levels (≥10 ng/mL), a Gleason score≥8, and metastatic disease (any T, N+/M+) than in those with low PSA levels, a low Gleason score, and non-metastatic disease (each P<0.05). In conclusion, low levels of hMOB3B are closely associated with aggressive clinicopathologic features in patients with PCa. Our results suggest that hMOB3B may act as a tumor suppressor in human PCa. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-4479949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-44799492015-07-01 Lower Levels of Human MOB3B Are Associated with Prostate Cancer Susceptibility and Aggressive Clinicopathological Characteristics Kim, Eun-Ah Kim, Ye-Hwan Kang, Ho Won Yoon, Hyung-Yoon Kim, Won Tae Kim, Yong-June Yun, Seok-Joong Moon, Sung-Kwon Choi, Yung Hyun Kim, Isaac Yi Lee, Sang-Cheol Kim, Wun-Jae J Korean Med Sci Original Article Mps one binder (MOB) proteins are integral components of signaling pathways that control important cellular processes, such as mitotic exit, centrosome duplication, apoptosis, and cell proliferation. However, the biochemical and cellular functions of the human MOB (hMOB) protein family remain largely unknown. The present study investigated the association between hMOB3B expression and clinicopathological characteristics of prostate cancer (PCa).Study subjects included 137 PCa patients and 137 age-matched benign prostatic hyperplasia (BPH) patients. hMOB3B expression was estimated using real-time PCR and compared with clinicopathological parameters of PCa. hMOB3B mRNA expression was significantly lower in PCa tissues than in BPH control tissues (P<0.001). According to receiver operating characteristics curve analysis, the sensitivity of hMOB3B expression for PCa diagnosis was 84.7%, with a specificity of 86% (AUC=0.910; 95% CI=0.869-0.941; P<0.001). hMOB3B expression was significantly lower in patients with elevated prostate specific antigen (PSA) levels (≥10 ng/mL), a Gleason score≥8, and metastatic disease (any T, N+/M+) than in those with low PSA levels, a low Gleason score, and non-metastatic disease (each P<0.05). In conclusion, low levels of hMOB3B are closely associated with aggressive clinicopathologic features in patients with PCa. Our results suggest that hMOB3B may act as a tumor suppressor in human PCa. GRAPHICAL ABSTRACT: [Image: see text] The Korean Academy of Medical Sciences 2015-07 2015-06-10 /pmc/articles/PMC4479949/ /pubmed/26130958 http://dx.doi.org/10.3346/jkms.2015.30.7.937 Text en © 2015 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Eun-Ah Kim, Ye-Hwan Kang, Ho Won Yoon, Hyung-Yoon Kim, Won Tae Kim, Yong-June Yun, Seok-Joong Moon, Sung-Kwon Choi, Yung Hyun Kim, Isaac Yi Lee, Sang-Cheol Kim, Wun-Jae Lower Levels of Human MOB3B Are Associated with Prostate Cancer Susceptibility and Aggressive Clinicopathological Characteristics |
title | Lower Levels of Human MOB3B Are Associated with Prostate Cancer Susceptibility and Aggressive Clinicopathological Characteristics |
title_full | Lower Levels of Human MOB3B Are Associated with Prostate Cancer Susceptibility and Aggressive Clinicopathological Characteristics |
title_fullStr | Lower Levels of Human MOB3B Are Associated with Prostate Cancer Susceptibility and Aggressive Clinicopathological Characteristics |
title_full_unstemmed | Lower Levels of Human MOB3B Are Associated with Prostate Cancer Susceptibility and Aggressive Clinicopathological Characteristics |
title_short | Lower Levels of Human MOB3B Are Associated with Prostate Cancer Susceptibility and Aggressive Clinicopathological Characteristics |
title_sort | lower levels of human mob3b are associated with prostate cancer susceptibility and aggressive clinicopathological characteristics |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479949/ https://www.ncbi.nlm.nih.gov/pubmed/26130958 http://dx.doi.org/10.3346/jkms.2015.30.7.937 |
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