Cargando…
MRI Findings and Prediction of Time to Progression of Patients with Hepatocellular Carcinoma Treated with Drug-eluting Bead Transcatheter Arterial Chemoembolization
The purpose of this study was to investigate the utility of MRI findings after drug-eluting beads (DEB) - transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma in predicting time to progression (TTP). This study included 48 patients with 60 lesions who underwent liver MRI with...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479953/ https://www.ncbi.nlm.nih.gov/pubmed/26130962 http://dx.doi.org/10.3346/jkms.2015.30.7.965 |
_version_ | 1782378097851498496 |
---|---|
author | Lee, Seungsoo Kim, Kyung Ah Park, Mi-Suk Choi, Sun Young |
author_facet | Lee, Seungsoo Kim, Kyung Ah Park, Mi-Suk Choi, Sun Young |
author_sort | Lee, Seungsoo |
collection | PubMed |
description | The purpose of this study was to investigate the utility of MRI findings after drug-eluting beads (DEB) - transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma in predicting time to progression (TTP). This study included 48 patients with 60 lesions who underwent liver MRI within 3 months after DEB-TACE. MRI was assessed for arterial enhancement pattern, late washout, arterioportal shunt, signal intensity on T2-weighted image, intratumoral septa, enhancing tissue on subtraction images, and treatment response. Cox-regression analysis was performed to identify independent factors to predict TTP. TTP was calculated using the Kaplan-Meier method with the log-rank test. Per lesion, 30 achieved complete remission, 22 had a partial response, and the remaining 8 lesions displayed stable disease on MRI. Arterial enhancement pattern, washout and enhancing tissue on subtraction images from MRI were associated with viable tumor on the last follow-up computerized tomography. Arterial enhancement, washout and enhancing tissue on subtraction images were significant predictors of TTP, but only enhancing tissue on subtraction images remained a significant predictor of TTP (P=0.018) in the multivariate analysis. TTP was longer in the group without enhancing tissue on subtraction images compared to the group with enhancing tissue (601 days vs. 287 days, P<0.001). Enhancing tissue on subtraction images from MRI after DEB-TACE is predictive for longer TTP. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-4479953 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-44799532015-07-01 MRI Findings and Prediction of Time to Progression of Patients with Hepatocellular Carcinoma Treated with Drug-eluting Bead Transcatheter Arterial Chemoembolization Lee, Seungsoo Kim, Kyung Ah Park, Mi-Suk Choi, Sun Young J Korean Med Sci Original Article The purpose of this study was to investigate the utility of MRI findings after drug-eluting beads (DEB) - transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma in predicting time to progression (TTP). This study included 48 patients with 60 lesions who underwent liver MRI within 3 months after DEB-TACE. MRI was assessed for arterial enhancement pattern, late washout, arterioportal shunt, signal intensity on T2-weighted image, intratumoral septa, enhancing tissue on subtraction images, and treatment response. Cox-regression analysis was performed to identify independent factors to predict TTP. TTP was calculated using the Kaplan-Meier method with the log-rank test. Per lesion, 30 achieved complete remission, 22 had a partial response, and the remaining 8 lesions displayed stable disease on MRI. Arterial enhancement pattern, washout and enhancing tissue on subtraction images from MRI were associated with viable tumor on the last follow-up computerized tomography. Arterial enhancement, washout and enhancing tissue on subtraction images were significant predictors of TTP, but only enhancing tissue on subtraction images remained a significant predictor of TTP (P=0.018) in the multivariate analysis. TTP was longer in the group without enhancing tissue on subtraction images compared to the group with enhancing tissue (601 days vs. 287 days, P<0.001). Enhancing tissue on subtraction images from MRI after DEB-TACE is predictive for longer TTP. GRAPHICAL ABSTRACT: [Image: see text] The Korean Academy of Medical Sciences 2015-07 2015-06-10 /pmc/articles/PMC4479953/ /pubmed/26130962 http://dx.doi.org/10.3346/jkms.2015.30.7.965 Text en © 2015 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Seungsoo Kim, Kyung Ah Park, Mi-Suk Choi, Sun Young MRI Findings and Prediction of Time to Progression of Patients with Hepatocellular Carcinoma Treated with Drug-eluting Bead Transcatheter Arterial Chemoembolization |
title | MRI Findings and Prediction of Time to Progression of Patients with Hepatocellular Carcinoma Treated with Drug-eluting Bead Transcatheter Arterial Chemoembolization |
title_full | MRI Findings and Prediction of Time to Progression of Patients with Hepatocellular Carcinoma Treated with Drug-eluting Bead Transcatheter Arterial Chemoembolization |
title_fullStr | MRI Findings and Prediction of Time to Progression of Patients with Hepatocellular Carcinoma Treated with Drug-eluting Bead Transcatheter Arterial Chemoembolization |
title_full_unstemmed | MRI Findings and Prediction of Time to Progression of Patients with Hepatocellular Carcinoma Treated with Drug-eluting Bead Transcatheter Arterial Chemoembolization |
title_short | MRI Findings and Prediction of Time to Progression of Patients with Hepatocellular Carcinoma Treated with Drug-eluting Bead Transcatheter Arterial Chemoembolization |
title_sort | mri findings and prediction of time to progression of patients with hepatocellular carcinoma treated with drug-eluting bead transcatheter arterial chemoembolization |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479953/ https://www.ncbi.nlm.nih.gov/pubmed/26130962 http://dx.doi.org/10.3346/jkms.2015.30.7.965 |
work_keys_str_mv | AT leeseungsoo mrifindingsandpredictionoftimetoprogressionofpatientswithhepatocellularcarcinomatreatedwithdrugelutingbeadtranscatheterarterialchemoembolization AT kimkyungah mrifindingsandpredictionoftimetoprogressionofpatientswithhepatocellularcarcinomatreatedwithdrugelutingbeadtranscatheterarterialchemoembolization AT parkmisuk mrifindingsandpredictionoftimetoprogressionofpatientswithhepatocellularcarcinomatreatedwithdrugelutingbeadtranscatheterarterialchemoembolization AT choisunyoung mrifindingsandpredictionoftimetoprogressionofpatientswithhepatocellularcarcinomatreatedwithdrugelutingbeadtranscatheterarterialchemoembolization |