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Reversal of Hypoglycemia Unawareness with a Single-donor, Marginal Dose Allogeneic Islet Transplantation in Korea: A Case Report
Pancreatic islet transplantation is a physiologically advantageous and minimally invasive procedure for the treatment of type 1 diabetes mellitus. Here, we describe the first reported case of successful allogeneic islet transplantation alone, using single-donor, marginal-dose islets in a Korean pati...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479957/ https://www.ncbi.nlm.nih.gov/pubmed/26130966 http://dx.doi.org/10.3346/jkms.2015.30.7.991 |
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author | Yang, Hae Kyung Ham, Dong-Sik Park, Heon-Seok Rhee, Marie You, Young Hye Kim, Min Jung Kim, Ji-Won Lee, Seung-Hwan Hong, Tae Ho Choi, Byung Gil Cho, Jae Hyoung Yoon, Kun-Ho |
author_facet | Yang, Hae Kyung Ham, Dong-Sik Park, Heon-Seok Rhee, Marie You, Young Hye Kim, Min Jung Kim, Ji-Won Lee, Seung-Hwan Hong, Tae Ho Choi, Byung Gil Cho, Jae Hyoung Yoon, Kun-Ho |
author_sort | Yang, Hae Kyung |
collection | PubMed |
description | Pancreatic islet transplantation is a physiologically advantageous and minimally invasive procedure for the treatment of type 1 diabetes mellitus. Here, we describe the first reported case of successful allogeneic islet transplantation alone, using single-donor, marginal-dose islets in a Korean patient. A 59-yr-old patient with type 1 diabetes mellitus, who suffered from recurrent severe hypoglycemia, received 4,163 islet equivalents/kg from a single brain-death donor. Isolated islets were infused intraportally without any complications. The immunosuppressive regimen was based on the Edmonton protocol, but the maintenance dosage was reduced because of mucositis and leukopenia. Although insulin independence was not achieved, the patient showed stabilized blood glucose concentration, reduced insulin dosage and reversal of hypoglycemic unawareness, even with marginal dose of islets and reduced immunosuppressant. Islet transplantation may successfully improve endogenous insulin production and glycemic stability in subjects with type 1 diabetes mellitus. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-4479957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-44799572015-07-01 Reversal of Hypoglycemia Unawareness with a Single-donor, Marginal Dose Allogeneic Islet Transplantation in Korea: A Case Report Yang, Hae Kyung Ham, Dong-Sik Park, Heon-Seok Rhee, Marie You, Young Hye Kim, Min Jung Kim, Ji-Won Lee, Seung-Hwan Hong, Tae Ho Choi, Byung Gil Cho, Jae Hyoung Yoon, Kun-Ho J Korean Med Sci Case Report Pancreatic islet transplantation is a physiologically advantageous and minimally invasive procedure for the treatment of type 1 diabetes mellitus. Here, we describe the first reported case of successful allogeneic islet transplantation alone, using single-donor, marginal-dose islets in a Korean patient. A 59-yr-old patient with type 1 diabetes mellitus, who suffered from recurrent severe hypoglycemia, received 4,163 islet equivalents/kg from a single brain-death donor. Isolated islets were infused intraportally without any complications. The immunosuppressive regimen was based on the Edmonton protocol, but the maintenance dosage was reduced because of mucositis and leukopenia. Although insulin independence was not achieved, the patient showed stabilized blood glucose concentration, reduced insulin dosage and reversal of hypoglycemic unawareness, even with marginal dose of islets and reduced immunosuppressant. Islet transplantation may successfully improve endogenous insulin production and glycemic stability in subjects with type 1 diabetes mellitus. GRAPHICAL ABSTRACT: [Image: see text] The Korean Academy of Medical Sciences 2015-07 2015-06-10 /pmc/articles/PMC4479957/ /pubmed/26130966 http://dx.doi.org/10.3346/jkms.2015.30.7.991 Text en © 2015 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Yang, Hae Kyung Ham, Dong-Sik Park, Heon-Seok Rhee, Marie You, Young Hye Kim, Min Jung Kim, Ji-Won Lee, Seung-Hwan Hong, Tae Ho Choi, Byung Gil Cho, Jae Hyoung Yoon, Kun-Ho Reversal of Hypoglycemia Unawareness with a Single-donor, Marginal Dose Allogeneic Islet Transplantation in Korea: A Case Report |
title | Reversal of Hypoglycemia Unawareness with a Single-donor, Marginal Dose Allogeneic Islet Transplantation in Korea: A Case Report |
title_full | Reversal of Hypoglycemia Unawareness with a Single-donor, Marginal Dose Allogeneic Islet Transplantation in Korea: A Case Report |
title_fullStr | Reversal of Hypoglycemia Unawareness with a Single-donor, Marginal Dose Allogeneic Islet Transplantation in Korea: A Case Report |
title_full_unstemmed | Reversal of Hypoglycemia Unawareness with a Single-donor, Marginal Dose Allogeneic Islet Transplantation in Korea: A Case Report |
title_short | Reversal of Hypoglycemia Unawareness with a Single-donor, Marginal Dose Allogeneic Islet Transplantation in Korea: A Case Report |
title_sort | reversal of hypoglycemia unawareness with a single-donor, marginal dose allogeneic islet transplantation in korea: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479957/ https://www.ncbi.nlm.nih.gov/pubmed/26130966 http://dx.doi.org/10.3346/jkms.2015.30.7.991 |
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