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Influence of carbapenem resistance on mortality of patients with Pseudomonas aeruginosa infection: a meta-analysis
Treatment of infectious diseases caused by the carbapenem-resistant Pseudomonas aeruginosa (CRPA) is becoming more challenging with each passing year. We conducted a meta-analysis to assess the impact of carbapenem resistance on mortality of patients with P. aeruginosa infection. We searched PUBMED,...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479982/ https://www.ncbi.nlm.nih.gov/pubmed/26108476 http://dx.doi.org/10.1038/srep11715 |
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author | Liu, Qianqian Li, Xiaoqing Li, Wenzhang Du, Xinmiao He, Jian-Qing Tao, Chuanmin Feng, Yulin |
author_facet | Liu, Qianqian Li, Xiaoqing Li, Wenzhang Du, Xinmiao He, Jian-Qing Tao, Chuanmin Feng, Yulin |
author_sort | Liu, Qianqian |
collection | PubMed |
description | Treatment of infectious diseases caused by the carbapenem-resistant Pseudomonas aeruginosa (CRPA) is becoming more challenging with each passing year. We conducted a meta-analysis to assess the impact of carbapenem resistance on mortality of patients with P. aeruginosa infection. We searched PUBMED, Web of science, EMBASE, Google Scholar and the Cochrane Library up to December 25, 2014, to identify published cohort or case-control studies. 17 studies, including 6660 patients carrying P. aeruginosa, were identified. The pooling analysis indicated that patients infected with CRPA had significantly higher mortality than those infected with carbapenem-susceptible P. aeruginosa (CSPA) (crude OR = 1.64; 95%CI = 1.40, 1.93; adjusted OR = 2.38; 95%CI = 1.53, 3.69). The elevated risk of mortality in patients with CRPA infection was not lessened when stratified by study design, sites of infection, or type of carbapenem, except that the estimate effect vanished in CRPA high-incidence region, South America (crude OR = 1.12; 95%CI = 0.64, 1.99). Begg’s (z = 0.95, p = 0.34) and Egger’s test (t = 1.23, p = 0.24) showed no evidence of publication bias. Our results suggest that carbapenem resistance may increase the mortality of patients with P. aeruginosa infection, whether under univariate or multivariate analysis. |
format | Online Article Text |
id | pubmed-4479982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-44799822015-06-29 Influence of carbapenem resistance on mortality of patients with Pseudomonas aeruginosa infection: a meta-analysis Liu, Qianqian Li, Xiaoqing Li, Wenzhang Du, Xinmiao He, Jian-Qing Tao, Chuanmin Feng, Yulin Sci Rep Article Treatment of infectious diseases caused by the carbapenem-resistant Pseudomonas aeruginosa (CRPA) is becoming more challenging with each passing year. We conducted a meta-analysis to assess the impact of carbapenem resistance on mortality of patients with P. aeruginosa infection. We searched PUBMED, Web of science, EMBASE, Google Scholar and the Cochrane Library up to December 25, 2014, to identify published cohort or case-control studies. 17 studies, including 6660 patients carrying P. aeruginosa, were identified. The pooling analysis indicated that patients infected with CRPA had significantly higher mortality than those infected with carbapenem-susceptible P. aeruginosa (CSPA) (crude OR = 1.64; 95%CI = 1.40, 1.93; adjusted OR = 2.38; 95%CI = 1.53, 3.69). The elevated risk of mortality in patients with CRPA infection was not lessened when stratified by study design, sites of infection, or type of carbapenem, except that the estimate effect vanished in CRPA high-incidence region, South America (crude OR = 1.12; 95%CI = 0.64, 1.99). Begg’s (z = 0.95, p = 0.34) and Egger’s test (t = 1.23, p = 0.24) showed no evidence of publication bias. Our results suggest that carbapenem resistance may increase the mortality of patients with P. aeruginosa infection, whether under univariate or multivariate analysis. Nature Publishing Group 2015-06-25 /pmc/articles/PMC4479982/ /pubmed/26108476 http://dx.doi.org/10.1038/srep11715 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Liu, Qianqian Li, Xiaoqing Li, Wenzhang Du, Xinmiao He, Jian-Qing Tao, Chuanmin Feng, Yulin Influence of carbapenem resistance on mortality of patients with Pseudomonas aeruginosa infection: a meta-analysis |
title | Influence of carbapenem resistance on mortality of patients with Pseudomonas aeruginosa infection: a meta-analysis |
title_full | Influence of carbapenem resistance on mortality of patients with Pseudomonas aeruginosa infection: a meta-analysis |
title_fullStr | Influence of carbapenem resistance on mortality of patients with Pseudomonas aeruginosa infection: a meta-analysis |
title_full_unstemmed | Influence of carbapenem resistance on mortality of patients with Pseudomonas aeruginosa infection: a meta-analysis |
title_short | Influence of carbapenem resistance on mortality of patients with Pseudomonas aeruginosa infection: a meta-analysis |
title_sort | influence of carbapenem resistance on mortality of patients with pseudomonas aeruginosa infection: a meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479982/ https://www.ncbi.nlm.nih.gov/pubmed/26108476 http://dx.doi.org/10.1038/srep11715 |
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