Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration

Mechanical stress and aging are major risk factors of cartilage degeneration. Human studies have previously reported that oxidative damage increased, while SOD2 protein was reciprocally downregulated in osteoarthritic degenerated cartilage. However, it remains unclear whether mitochondrial superoxid...

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Detalles Bibliográficos
Autores principales: Koike, Masato, Nojiri, Hidetoshi, Ozawa, Yusuke, Watanabe, Kenji, Muramatsu, Yuta, Kaneko, Haruka, Morikawa, Daichi, Kobayashi, Keiji, Saita, Yoshitomo, Sasho, Takahisa, Shirasawa, Takuji, Yokote, Koutaro, Kaneko, Kazuo, Shimizu, Takahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480010/
https://www.ncbi.nlm.nih.gov/pubmed/26108578
http://dx.doi.org/10.1038/srep11722

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