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Correlation of IL-17 Level in Synovia and Severity of Knee Osteoarthritis

BACKGROUND: The aim of this study was to evaluate the role of interleukin-17 (IL-17) level in synovia and its relationship with the severity of knee osteoarthritis (OA). MATERIAL/METHODS: We enrolled 226 OA patients and 106 controls in this study. The symptomatic/radiation severity of OA was assesse...

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Autores principales: Liu, Yingsong, Peng, Hao, Meng, Zhao, Wei, Mingzhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480114/
https://www.ncbi.nlm.nih.gov/pubmed/26076201
http://dx.doi.org/10.12659/MSM.893771
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author Liu, Yingsong
Peng, Hao
Meng, Zhao
Wei, Mingzhu
author_facet Liu, Yingsong
Peng, Hao
Meng, Zhao
Wei, Mingzhu
author_sort Liu, Yingsong
collection PubMed
description BACKGROUND: The aim of this study was to evaluate the role of interleukin-17 (IL-17) level in synovia and its relationship with the severity of knee osteoarthritis (OA). MATERIAL/METHODS: We enrolled 226 OA patients and 106 controls in this study. The symptomatic/radiation severity of OA was assessed by the Western Ontario McMaster University Osteoarthritis Index (WOMAC) pain score/Kellgren-Lawrence (KL) grading system. Serum IL-17 levels were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: Synovia IL-17 levels were significantly higher in OA patients compared with controls (P<0.01), and were negatively correlated with OA severity. IL-17 level gradually decreased among different phases but lacked statistical significance. CONCLUSIONS: IL-17 might play a crucial role in the pathogenesis of OA and is closely related to pain. Blocking the IL-17 signaling pathway may delay pain related to OA.
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spelling pubmed-44801142015-07-01 Correlation of IL-17 Level in Synovia and Severity of Knee Osteoarthritis Liu, Yingsong Peng, Hao Meng, Zhao Wei, Mingzhu Med Sci Monit Clinical Research BACKGROUND: The aim of this study was to evaluate the role of interleukin-17 (IL-17) level in synovia and its relationship with the severity of knee osteoarthritis (OA). MATERIAL/METHODS: We enrolled 226 OA patients and 106 controls in this study. The symptomatic/radiation severity of OA was assessed by the Western Ontario McMaster University Osteoarthritis Index (WOMAC) pain score/Kellgren-Lawrence (KL) grading system. Serum IL-17 levels were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: Synovia IL-17 levels were significantly higher in OA patients compared with controls (P<0.01), and were negatively correlated with OA severity. IL-17 level gradually decreased among different phases but lacked statistical significance. CONCLUSIONS: IL-17 might play a crucial role in the pathogenesis of OA and is closely related to pain. Blocking the IL-17 signaling pathway may delay pain related to OA. International Scientific Literature, Inc. 2015-06-15 /pmc/articles/PMC4480114/ /pubmed/26076201 http://dx.doi.org/10.12659/MSM.893771 Text en © Med Sci Monit, 2015 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Clinical Research
Liu, Yingsong
Peng, Hao
Meng, Zhao
Wei, Mingzhu
Correlation of IL-17 Level in Synovia and Severity of Knee Osteoarthritis
title Correlation of IL-17 Level in Synovia and Severity of Knee Osteoarthritis
title_full Correlation of IL-17 Level in Synovia and Severity of Knee Osteoarthritis
title_fullStr Correlation of IL-17 Level in Synovia and Severity of Knee Osteoarthritis
title_full_unstemmed Correlation of IL-17 Level in Synovia and Severity of Knee Osteoarthritis
title_short Correlation of IL-17 Level in Synovia and Severity of Knee Osteoarthritis
title_sort correlation of il-17 level in synovia and severity of knee osteoarthritis
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480114/
https://www.ncbi.nlm.nih.gov/pubmed/26076201
http://dx.doi.org/10.12659/MSM.893771
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