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Cognitive and neural strategies during control of the anterior cingulate cortex by fMRI neurofeedback in patients with schizophrenia

Cognitive functioning is impaired in patients with schizophrenia, leading to significant disabilities in everyday functioning. Its improvement is an important treatment target. Neurofeedback (NF) seems a promising method to address the neural dysfunctions underlying those cognitive impairments. The...

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Autores principales: Cordes, Julia S., Mathiak, Krystyna A., Dyck, Miriam, Alawi, Eliza M., Gaber, Tilman J., Zepf, Florian D., Klasen, Martin, Zvyagintsev, Mikhail, Gur, Ruben C., Mathiak, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480149/
https://www.ncbi.nlm.nih.gov/pubmed/26161073
http://dx.doi.org/10.3389/fnbeh.2015.00169
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author Cordes, Julia S.
Mathiak, Krystyna A.
Dyck, Miriam
Alawi, Eliza M.
Gaber, Tilman J.
Zepf, Florian D.
Klasen, Martin
Zvyagintsev, Mikhail
Gur, Ruben C.
Mathiak, Klaus
author_facet Cordes, Julia S.
Mathiak, Krystyna A.
Dyck, Miriam
Alawi, Eliza M.
Gaber, Tilman J.
Zepf, Florian D.
Klasen, Martin
Zvyagintsev, Mikhail
Gur, Ruben C.
Mathiak, Klaus
author_sort Cordes, Julia S.
collection PubMed
description Cognitive functioning is impaired in patients with schizophrenia, leading to significant disabilities in everyday functioning. Its improvement is an important treatment target. Neurofeedback (NF) seems a promising method to address the neural dysfunctions underlying those cognitive impairments. The anterior cingulate cortex (ACC), a central hub for cognitive processing, is one of the brain regions known to be dysfunctional in schizophrenia. Here we conducted NF training based on real-time functional magnetic resonance imaging (fMRI) in patients with schizophrenia to enable them to control their ACC activity. Training was performed over 3 days in a group of 11 patients with schizophrenia and 11 healthy controls. Social feedback was provided in accordance with the evoked activity in the selected region of interest (ROI). Neural and cognitive strategies were examined off-line. Both groups learned to control the activity of their ACC but used different neural strategies: patients activated the dorsal and healthy controls the rostral subdivision. Patients mainly used imagination of music to elicit activity and the control group imagination of sports. In a stepwise regression analysis, the difference in neural control did not result from the differences in cognitive strategies but from diagnosis alone. Based on social reinforcers, patients with schizophrenia can learn to regulate localized brain activity. However, cognitive strategies and neural network location differ from healthy controls. These data emphasize that for therapeutic interventions in patients with schizophrenia compensatory strategies may emerge. Specific cognitive skills or specific dysfunctional networks should be addressed to train impaired skills. Social NF based on fMRI may be one method to accomplish precise learning targets.
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spelling pubmed-44801492015-07-09 Cognitive and neural strategies during control of the anterior cingulate cortex by fMRI neurofeedback in patients with schizophrenia Cordes, Julia S. Mathiak, Krystyna A. Dyck, Miriam Alawi, Eliza M. Gaber, Tilman J. Zepf, Florian D. Klasen, Martin Zvyagintsev, Mikhail Gur, Ruben C. Mathiak, Klaus Front Behav Neurosci Neuroscience Cognitive functioning is impaired in patients with schizophrenia, leading to significant disabilities in everyday functioning. Its improvement is an important treatment target. Neurofeedback (NF) seems a promising method to address the neural dysfunctions underlying those cognitive impairments. The anterior cingulate cortex (ACC), a central hub for cognitive processing, is one of the brain regions known to be dysfunctional in schizophrenia. Here we conducted NF training based on real-time functional magnetic resonance imaging (fMRI) in patients with schizophrenia to enable them to control their ACC activity. Training was performed over 3 days in a group of 11 patients with schizophrenia and 11 healthy controls. Social feedback was provided in accordance with the evoked activity in the selected region of interest (ROI). Neural and cognitive strategies were examined off-line. Both groups learned to control the activity of their ACC but used different neural strategies: patients activated the dorsal and healthy controls the rostral subdivision. Patients mainly used imagination of music to elicit activity and the control group imagination of sports. In a stepwise regression analysis, the difference in neural control did not result from the differences in cognitive strategies but from diagnosis alone. Based on social reinforcers, patients with schizophrenia can learn to regulate localized brain activity. However, cognitive strategies and neural network location differ from healthy controls. These data emphasize that for therapeutic interventions in patients with schizophrenia compensatory strategies may emerge. Specific cognitive skills or specific dysfunctional networks should be addressed to train impaired skills. Social NF based on fMRI may be one method to accomplish precise learning targets. Frontiers Media S.A. 2015-06-25 /pmc/articles/PMC4480149/ /pubmed/26161073 http://dx.doi.org/10.3389/fnbeh.2015.00169 Text en Copyright © 2015 Cordes, Mathiak, Dyck, Alawi, Gaber, Zepf, Klasen, Zvyagintsev, Gur and Mathiak. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Cordes, Julia S.
Mathiak, Krystyna A.
Dyck, Miriam
Alawi, Eliza M.
Gaber, Tilman J.
Zepf, Florian D.
Klasen, Martin
Zvyagintsev, Mikhail
Gur, Ruben C.
Mathiak, Klaus
Cognitive and neural strategies during control of the anterior cingulate cortex by fMRI neurofeedback in patients with schizophrenia
title Cognitive and neural strategies during control of the anterior cingulate cortex by fMRI neurofeedback in patients with schizophrenia
title_full Cognitive and neural strategies during control of the anterior cingulate cortex by fMRI neurofeedback in patients with schizophrenia
title_fullStr Cognitive and neural strategies during control of the anterior cingulate cortex by fMRI neurofeedback in patients with schizophrenia
title_full_unstemmed Cognitive and neural strategies during control of the anterior cingulate cortex by fMRI neurofeedback in patients with schizophrenia
title_short Cognitive and neural strategies during control of the anterior cingulate cortex by fMRI neurofeedback in patients with schizophrenia
title_sort cognitive and neural strategies during control of the anterior cingulate cortex by fmri neurofeedback in patients with schizophrenia
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480149/
https://www.ncbi.nlm.nih.gov/pubmed/26161073
http://dx.doi.org/10.3389/fnbeh.2015.00169
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