Induction Murine Models of Chronic Fatigue Syndrome by Brucella abortus Antigen Injections: Is Anemia Induced or Not?

To investigate whether Brucella abortus (BA) antigen injections lead to anemia, and to establish an appropriate Chronic Fatigue Syndrome (CFS) animal model by BA injections, 6 repeated injections of BA antigen were fulfilled every 2 weeks. At a high dose of 1∗10(10) particles/mouse, anemia was induc...

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Autores principales: Moriya, Junji, He, Qiang, Uenishi, Hiroaki, Akazawa, Sumiyo, Yamakawa, Jun-ichi, Kobayashi, Junji, Ishigaki, Yasuhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480237/
https://www.ncbi.nlm.nih.gov/pubmed/26171388
http://dx.doi.org/10.1155/2015/191489
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author Moriya, Junji
He, Qiang
Uenishi, Hiroaki
Akazawa, Sumiyo
Yamakawa, Jun-ichi
Kobayashi, Junji
Ishigaki, Yasuhito
author_facet Moriya, Junji
He, Qiang
Uenishi, Hiroaki
Akazawa, Sumiyo
Yamakawa, Jun-ichi
Kobayashi, Junji
Ishigaki, Yasuhito
author_sort Moriya, Junji
collection PubMed
description To investigate whether Brucella abortus (BA) antigen injections lead to anemia, and to establish an appropriate Chronic Fatigue Syndrome (CFS) animal model by BA injections, 6 repeated injections of BA antigen were fulfilled every 2 weeks. At a high dose of 1∗10(10) particles/mouse, anemia was induced within 2 weeks and then recovered a lot at the end of the research, while at a moderate dose of 1∗10(8) (3 injections) shifting to 1∗10(9)/mouse (3 injections) anemia was absent. In both groups running wheel activity remained very low even 6 weeks after the last injection.
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spelling pubmed-44802372015-07-13 Induction Murine Models of Chronic Fatigue Syndrome by Brucella abortus Antigen Injections: Is Anemia Induced or Not? Moriya, Junji He, Qiang Uenishi, Hiroaki Akazawa, Sumiyo Yamakawa, Jun-ichi Kobayashi, Junji Ishigaki, Yasuhito Biomed Res Int Research Article To investigate whether Brucella abortus (BA) antigen injections lead to anemia, and to establish an appropriate Chronic Fatigue Syndrome (CFS) animal model by BA injections, 6 repeated injections of BA antigen were fulfilled every 2 weeks. At a high dose of 1∗10(10) particles/mouse, anemia was induced within 2 weeks and then recovered a lot at the end of the research, while at a moderate dose of 1∗10(8) (3 injections) shifting to 1∗10(9)/mouse (3 injections) anemia was absent. In both groups running wheel activity remained very low even 6 weeks after the last injection. Hindawi Publishing Corporation 2015 2015-06-11 /pmc/articles/PMC4480237/ /pubmed/26171388 http://dx.doi.org/10.1155/2015/191489 Text en Copyright © 2015 Junji Moriya et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Moriya, Junji
He, Qiang
Uenishi, Hiroaki
Akazawa, Sumiyo
Yamakawa, Jun-ichi
Kobayashi, Junji
Ishigaki, Yasuhito
Induction Murine Models of Chronic Fatigue Syndrome by Brucella abortus Antigen Injections: Is Anemia Induced or Not?
title Induction Murine Models of Chronic Fatigue Syndrome by Brucella abortus Antigen Injections: Is Anemia Induced or Not?
title_full Induction Murine Models of Chronic Fatigue Syndrome by Brucella abortus Antigen Injections: Is Anemia Induced or Not?
title_fullStr Induction Murine Models of Chronic Fatigue Syndrome by Brucella abortus Antigen Injections: Is Anemia Induced or Not?
title_full_unstemmed Induction Murine Models of Chronic Fatigue Syndrome by Brucella abortus Antigen Injections: Is Anemia Induced or Not?
title_short Induction Murine Models of Chronic Fatigue Syndrome by Brucella abortus Antigen Injections: Is Anemia Induced or Not?
title_sort induction murine models of chronic fatigue syndrome by brucella abortus antigen injections: is anemia induced or not?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480237/
https://www.ncbi.nlm.nih.gov/pubmed/26171388
http://dx.doi.org/10.1155/2015/191489
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