Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013

Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynony...

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Detalles Bibliográficos
Autores principales: Hawkes, Michael, Conroy, Andrea L., Opoka, Robert O., Namasopo, Sophie, Zhong, Kathleen, Liles, W. Conrad, John, Chandy C., Kain, Kevin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2015
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480400/
https://www.ncbi.nlm.nih.gov/pubmed/26079933
http://dx.doi.org/10.3201/eid2107.150213
Descripción
Sumario:Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynonymous, single-nucleotide polymorphism associated with prolonged parasite clearance.

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