Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013

Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynony...

Descripción completa

Detalles Bibliográficos
Autores principales: Hawkes, Michael, Conroy, Andrea L., Opoka, Robert O., Namasopo, Sophie, Zhong, Kathleen, Liles, W. Conrad, John, Chandy C., Kain, Kevin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2015
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480400/
https://www.ncbi.nlm.nih.gov/pubmed/26079933
http://dx.doi.org/10.3201/eid2107.150213
_version_ 1782378155984551936
author Hawkes, Michael
Conroy, Andrea L.
Opoka, Robert O.
Namasopo, Sophie
Zhong, Kathleen
Liles, W. Conrad
John, Chandy C.
Kain, Kevin C.
author_facet Hawkes, Michael
Conroy, Andrea L.
Opoka, Robert O.
Namasopo, Sophie
Zhong, Kathleen
Liles, W. Conrad
John, Chandy C.
Kain, Kevin C.
author_sort Hawkes, Michael
collection PubMed
description Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynonymous, single-nucleotide polymorphism associated with prolonged parasite clearance.
format Online
Article
Text
id pubmed-4480400
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Centers for Disease Control and Prevention
record_format MEDLINE/PubMed
spelling pubmed-44804002015-07-01 Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013 Hawkes, Michael Conroy, Andrea L. Opoka, Robert O. Namasopo, Sophie Zhong, Kathleen Liles, W. Conrad John, Chandy C. Kain, Kevin C. Emerg Infect Dis Dispatch Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynonymous, single-nucleotide polymorphism associated with prolonged parasite clearance. Centers for Disease Control and Prevention 2015-07 /pmc/articles/PMC4480400/ /pubmed/26079933 http://dx.doi.org/10.3201/eid2107.150213 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
Hawkes, Michael
Conroy, Andrea L.
Opoka, Robert O.
Namasopo, Sophie
Zhong, Kathleen
Liles, W. Conrad
John, Chandy C.
Kain, Kevin C.
Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013
title Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013
title_full Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013
title_fullStr Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013
title_full_unstemmed Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013
title_short Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011–2013
title_sort slow clearance of plasmodium falciparum in severe pediatric malaria, uganda, 2011–2013
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480400/
https://www.ncbi.nlm.nih.gov/pubmed/26079933
http://dx.doi.org/10.3201/eid2107.150213
work_keys_str_mv AT hawkesmichael slowclearanceofplasmodiumfalciparuminseverepediatricmalariauganda20112013
AT conroyandreal slowclearanceofplasmodiumfalciparuminseverepediatricmalariauganda20112013
AT opokaroberto slowclearanceofplasmodiumfalciparuminseverepediatricmalariauganda20112013
AT namasoposophie slowclearanceofplasmodiumfalciparuminseverepediatricmalariauganda20112013
AT zhongkathleen slowclearanceofplasmodiumfalciparuminseverepediatricmalariauganda20112013
AT lileswconrad slowclearanceofplasmodiumfalciparuminseverepediatricmalariauganda20112013
AT johnchandyc slowclearanceofplasmodiumfalciparuminseverepediatricmalariauganda20112013
AT kainkevinc slowclearanceofplasmodiumfalciparuminseverepediatricmalariauganda20112013

Ejemplares similares