Site-Specific, Intramolecular Cross-Linking of Pin1 Active Site Residues by the Lipid Electrophile 4-Oxo-2-nonenal

[Image: see text] Products of oxidative damage to lipids include 4-hydroxy-2-nonenal (HNE) and 4-oxo-2-nonenal (ONE), both of which are cytotoxic electrophiles. ONE reacts more rapidly with nucleophilic amino acid side chains, resulting in covalent protein adducts, including residue–residue cross-li...

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Detalles Bibliográficos
Autores principales: Aluise, Christopher D., Camarillo, Jeannie M., Shimozu, Yuki, Galligan, James J., Rose, Kristie L., Tallman, Keri A., Marnett, Lawrence J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480626/
https://www.ncbi.nlm.nih.gov/pubmed/25739016
http://dx.doi.org/10.1021/acs.chemrestox.5b00038

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