Cargando…

Glutamate and asparagine cataplerosis underlie glutamine addiction in melanoma

Glutamine dependence is a prominent feature of cancer metabolism, and here we show that melanoma cells, irrespective of their oncogenic background, depend on glutamine for growth. A quantitative audit of how carbon from glutamine is used showed that TCA-cycle-derived glutamate is, in most melanoma c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ratnikov, Boris, Aza-Blanc, Pedro, Ronai, Ze'ev A., Smith, Jeffrey W., Osterman, Andrei L., Scott, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480687/ https://www.ncbi.nlm.nih.gov/pubmed/25749035

Ejemplares similares

Metabolic rewiring in melanoma
por: Ratnikov, Boris I., et al.
Publicado: (2016)

Right on TARGET: glutamine metabolism in cancer
por: Ratnikov, Boris, et al.
Publicado: (2015)

Functional Specialization in Proline Biosynthesis of Melanoma
por: De Ingeniis, Jessica, et al.
Publicado: (2012)

Reduced Glutamate Turnover in the Putamen Is Linked With Automatic Habits in Human Cocaine Addiction
por: Ersche, Karen D., et al.
Publicado: (2021)

Translational Reprogramming Marks Adaptation to Asparagine Restriction in Cancer
por: Pathria, Gaurav, et al.
Publicado: (2019)

Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism
por: Hakimi, Parvin, et al.
Publicado: (2005)

Thermal decomposition of the amino acids glycine, cysteine, aspartic acid, asparagine, glutamic acid, glutamine, arginine and histidine
por: Weiss, Ingrid M., et al.
Publicado: (2018)

Controlling the prion propensity of glutamine/asparagine-rich proteins
por: Paul, Kacy R, et al.
Publicado: (2015)

Light-Independent Nitrogen Assimilation in Plant Leaves: Nitrate Incorporation into Glutamine, Glutamate, Aspartate, and Asparagine Traced by (15)N
por: Yoneyama, Tadakatsu, et al.
Publicado: (2020)

Asparagine, a critical limiting metabolite during glutamine starvation
por: Jiang, Jie, et al.
Publicado: (2018)

Rewired Notch/p53 by Numb’ing Mdm2
por: Kim, Hyungsoo, et al.
Publicado: (2018)

CALPA-IN NF1
por: Lazar, Ikrame, et al.
Publicado: (2018)

PRMT5 function and targeting in cancer
por: Kim, Hyungsoo, et al.
Publicado: (2020)

Deamidation Reactions of Asparagine- and Glutamine-Containing Dipeptides Investigated by Ion Spectroscopy
por: Kempkes, Lisanne J. M., et al.
Publicado: (2016)

Primary cilia sense glutamine availability and respond via asparagine synthetase
por: Steidl, Maria Elena, et al.
Publicado: (2023)

The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities
por: Qi, Jianfei, et al.
Publicado: (2010)

Hypoxia-inducible factors enhance glutamate signaling in cancer cells
por: Hu, Hongxia, et al.
Publicado: (2014)

Metabolic profiles of cysteine, methionine, glutamate, glutamine, arginine, aspartate, asparagine, alanine and glutathione in Streptococcus thermophilus during pH-controlled batch fermentations
por: Qiao, Yali, et al.
Publicado: (2018)

Comparison of SARS-CoV-2 RT-PCR on a high-throughput molecular diagnostic platform and the cobas SARS-CoV-2 test for the diagnostic of COVID-19 on various clinical samples
por: Opota, Onya, et al.
Publicado: (2020)

The Anaphase-Promoting Complex or Cyclosome Supports Cell Survival in Response to Endoplasmic Reticulum Stress
por: Chen, Meifan, et al.
Publicado: (2012)

Distinct effects of etoposide on glutamine-addicted neuroblastoma
por: Valter, Kadri, et al.
Publicado: (2019)

Improvement of Soybean Agrobacterium-Mediated Transformation Efficiency by Adding Glutamine and Asparagine into the Culture Media
por: Chen, Li, et al.
Publicado: (2018)

SLC1A5 provides glutamine and asparagine necessary for bone development in mice
por: Sharma, Deepika, et al.
Publicado: (2021)

In Vitro Anti-HIV-1 Activity of Chitosan Oligomers N-Conjugated with Asparagine and Glutamine
por: Karadeniz, Fatih
Publicado: (2023)

Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma
por: Liu, Meng-Xi, et al.
Publicado: (2018)

Targeting Glutamine Addiction in Gliomas
por: Obara-Michlewska, Marta, et al.
Publicado: (2020)

NQ-Flipper: recognition and correction of erroneous asparagine and glutamine side-chain rotamers in protein structures
por: Weichenberger, Christian X., et al.
Publicado: (2007)

Asparagine Is a Critical Limiting Metabolite for Vaccinia Virus Protein Synthesis during Glutamine Deprivation
por: Pant, Anil, et al.
Publicado: (2019)

Fibril-induced glutamine-/asparagine-rich prions recruit stress granule proteins in mammalian cells
por: Riemschoss, Katrin, et al.
Publicado: (2019)

Myeloma Cells Deplete Bone Marrow Glutamine and Inhibit Osteoblast Differentiation Limiting Asparagine Availability
por: Chiu, Martina, et al.
Publicado: (2020)

Targeting the Proline–Glutamine–Asparagine–Arginine Metabolic Axis in Amino Acid Starvation Cancer Therapy
por: Kuo, Macus Tien, et al.
Publicado: (2021)

Metabolic analysis of the asparagine and glutamine dynamics in an industrial Chinese hamster ovary fed‐batch process
por: Kirsch, Brian J., et al.
Publicado: (2022)

Addiction to Runx1 is partially attenuated by loss of p53 in the Eμ-Myc lymphoma model
por: Borland, Gillian, et al.
Publicado: (2016)

Rethinking glutamine metabolism and the regulation of glutamine addiction by oncogenes in cancer
por: Ni, Rui, et al.
Publicado: (2023)

Modeling the glutamate–glutamine neurotransmitter cycle
por: Shen, Jun
Publicado: (2013)

Glutamine and glutamate supplementation raise milk glutamine concentrations in lactating gilts
por: Manso, Helena Emilia CCC, et al.
Publicado: (2012)

The interplay of CDK4 and CDK6 in melanoma
por: Kollmann, Karoline, et al.
Publicado: (2019)

Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells
por: Hasegawa, Masanori, et al.
Publicado: (2016)

Molecular dynamic simulations of Escherichia colil-asparaginase to illuminate its role in deamination of asparagine and glutamine residues
por: Erva, Rajeswara Reddy, et al.
Publicado: (2015)

A Facile Synthesis of α-N-Ribosyl-Asparagine and α-N-Ribosyl-Glutamine Building Blocks
por: Speciale, Gaetano, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_3plob5fu5cqtqkv226hh1jhh7c