MUTYH mediates the toxicity of combined DNA 6-thioguanine and UVA radiation

The therapeutic thiopurines, including the immunosuppressant azathioprine (Aza) cause the accumulation of the UVA photosensitizer 6-thioguanine (6-TG) in the DNA of the patients' cells. DNA 6-TG and UVA are synergistically cytotoxic and their interaction causes oxidative damage. The MUTYH DNA g...

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Detalles Bibliográficos
Autores principales: Grasso, Francesca, Ruggieri, Vitalba, De Luca, Gabriele, Leopardi, Paola, Mancuso, Maria Teresa, Casorelli, Ida, Pichierri, Pietro, Karran, Peter, Bignami, Margherita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480694/
https://www.ncbi.nlm.nih.gov/pubmed/25638157

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