Adrenomedullin blockade induces regression of tumor neovessels through interference with vascular endothelial-cadherin signalling

The cellular and molecular mechanisms by which adrenomedullin (AM) blockade suppresses tumor neovessels are not well defined. Herein, we show that AM blockade using anti-AM and anti-AM receptors antibodies targets vascular endothelial cells (ECs) and vascular smooth muscle cells (VSMCs), and induces...

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Detalles Bibliográficos
Autores principales: Khalfaoui-Bendriss, Ghizlane, Dussault, Nadège, Fernandez-Sauze, Samantha, Berenguer-Daizé, Caroline, Sigaud, Romain, Delfino, Christine, Cayol, Mylène, Metellus, Philippe, Chinot, Olivier, Mabrouk, Kamel, Martin, Pierre-Marie, Ouafik, L'Houcine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480698/
https://www.ncbi.nlm.nih.gov/pubmed/25924235

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