Identifying the determinants of response to MDM2 inhibition

Previous reports have provided evidence that p53 mutation is a strong negative predictor of response to MDM2 inhibitors. However, this correlation is not absolute, as many p53(Mutant) cell lines have been reported to respond to MDM2 inhibition, while many p53(WT) cell lines have been shown not to re...

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Detalles Bibliográficos
Autores principales: Saiki, Anne Y., Caenepeel, Sean, Cosgrove, Elissa, Su, Cheng, Boedigheimer, Michael, Oliner, Jonathan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480710/
https://www.ncbi.nlm.nih.gov/pubmed/25730903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480710/
https://www.ncbi.nlm.nih.gov/pubmed/25730903

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