TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome

Somatic mutations of TP53 are among the most common in cancer and germline mutations of TP53 (usually missense) can cause Li-Fraumeni syndrome (LFS). Recently, recurrent genomic rearrangements in intron 1 of TP53 have been described in osteosarcoma (OS), a highly malignant neoplasm of bone belonging...

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Detalles Bibliográficos
Autores principales: Ribi, Sebastian, Baumhoer, Daniel, Lee, Kristy, Edison, Teo, Audrey S.M., Madan, Babita, Zhang, Kang, Kohlmann, Wendy K., Yao, Fei, Lee, Wah Heng, Hoi, Qiangze, Cai, Shaojiang, Woo, Xing Yi, Tan, Patrick, Jundt, Gernot, Smida, Jan, Nathrath, Michaela, Sung, Wing-Kin, Schiffman, Joshua D., Virshup, David M., Hillmer, Axel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480712/
https://www.ncbi.nlm.nih.gov/pubmed/25762628

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