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Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase
As widely recognized, tumor growth entails a close and complex cross-talk among cancer cells and the surrounding tumor microenvironment. We recently described the human RNASET2 gene as one key player of such microenvironmental cross-talk. Indeed, the protein encoded by this gene is an extracellular...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480721/ https://www.ncbi.nlm.nih.gov/pubmed/25797262 |
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author | Lualdi, Marta Pedrini, Edoardo Rea, Katia Monti, Laura Scaldaferri, Debora Gariboldi, Marzia Camporeale, Annalisa Ghia, Paolo Monti, Elena Tomassetti, Antonella Acquati, Francesco Taramelli, Roberto |
author_facet | Lualdi, Marta Pedrini, Edoardo Rea, Katia Monti, Laura Scaldaferri, Debora Gariboldi, Marzia Camporeale, Annalisa Ghia, Paolo Monti, Elena Tomassetti, Antonella Acquati, Francesco Taramelli, Roberto |
author_sort | Lualdi, Marta |
collection | PubMed |
description | As widely recognized, tumor growth entails a close and complex cross-talk among cancer cells and the surrounding tumor microenvironment. We recently described the human RNASET2 gene as one key player of such microenvironmental cross-talk. Indeed, the protein encoded by this gene is an extracellular RNase which is able to control cancer growth in a non-cell autonomous mode by inducing a sustained recruitment of immune-competent cells belonging to the monocyte/macrophage lineage within a growing tumor mass. Here, we asked whether this oncosuppressor gene is sensitive to stress challenges and whether it can trigger cell-intrinsic processes as well. Indeed, RNASET2 expression levels were consistently found to increase following stress induction. Moreover, changes in RNASET2 expression levels turned out to affect several cancer-related parameters in vitro in an ovarian cancer cell line model. Of note, a remarkable rearrangement of the actin cytoskeleton organization, together with changes in cell adhesion and motility, emerged as putative mechanisms by which such cell-autonomous role could occur. Altogether, these biological features allow to put forward the hypothesis that the RNASET2 protein can act as a molecular barrier for limiting the damages and tissue remodeling events occurring during the earlier step of cell transformation. |
format | Online Article Text |
id | pubmed-4480721 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-44807212015-06-26 Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase Lualdi, Marta Pedrini, Edoardo Rea, Katia Monti, Laura Scaldaferri, Debora Gariboldi, Marzia Camporeale, Annalisa Ghia, Paolo Monti, Elena Tomassetti, Antonella Acquati, Francesco Taramelli, Roberto Oncotarget Research Paper As widely recognized, tumor growth entails a close and complex cross-talk among cancer cells and the surrounding tumor microenvironment. We recently described the human RNASET2 gene as one key player of such microenvironmental cross-talk. Indeed, the protein encoded by this gene is an extracellular RNase which is able to control cancer growth in a non-cell autonomous mode by inducing a sustained recruitment of immune-competent cells belonging to the monocyte/macrophage lineage within a growing tumor mass. Here, we asked whether this oncosuppressor gene is sensitive to stress challenges and whether it can trigger cell-intrinsic processes as well. Indeed, RNASET2 expression levels were consistently found to increase following stress induction. Moreover, changes in RNASET2 expression levels turned out to affect several cancer-related parameters in vitro in an ovarian cancer cell line model. Of note, a remarkable rearrangement of the actin cytoskeleton organization, together with changes in cell adhesion and motility, emerged as putative mechanisms by which such cell-autonomous role could occur. Altogether, these biological features allow to put forward the hypothesis that the RNASET2 protein can act as a molecular barrier for limiting the damages and tissue remodeling events occurring during the earlier step of cell transformation. Impact Journals LLC 2015-03-08 /pmc/articles/PMC4480721/ /pubmed/25797262 Text en Copyright: © 2015 Lualdi et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Lualdi, Marta Pedrini, Edoardo Rea, Katia Monti, Laura Scaldaferri, Debora Gariboldi, Marzia Camporeale, Annalisa Ghia, Paolo Monti, Elena Tomassetti, Antonella Acquati, Francesco Taramelli, Roberto Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase |
title | Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase |
title_full | Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase |
title_fullStr | Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase |
title_full_unstemmed | Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase |
title_short | Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase |
title_sort | pleiotropic modes of action in tumor cells of rnaset2, an evolutionary highly conserved extracellular rnase |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480721/ https://www.ncbi.nlm.nih.gov/pubmed/25797262 |
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