MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2

Although microRNA-200a (miR-200a) is frequently downregulated in cancer, its role in side population (SP) has not been investigated. In this study, 101 pairs of primary hepatocellular carcinoma (HCC) tissues and matched normal control tissues were analyzed for miR-200a expression and its clinicopath...

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Autores principales: Yang, Xisheng, Wang, Jianlin, Qu, Shibin, Zhang, Hongtao, Ruan, Bai, Gao, Yuan, Ma, Ben, Wang, Xing, Wu, Nan, Li, Xiaolei, Dou, Kefeng, Li, Haimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480725/
https://www.ncbi.nlm.nih.gov/pubmed/25797260
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author Yang, Xisheng
Wang, Jianlin
Qu, Shibin
Zhang, Hongtao
Ruan, Bai
Gao, Yuan
Ma, Ben
Wang, Xing
Wu, Nan
Li, Xiaolei
Dou, Kefeng
Li, Haimin
author_facet Yang, Xisheng
Wang, Jianlin
Qu, Shibin
Zhang, Hongtao
Ruan, Bai
Gao, Yuan
Ma, Ben
Wang, Xing
Wu, Nan
Li, Xiaolei
Dou, Kefeng
Li, Haimin
author_sort Yang, Xisheng
collection PubMed
description Although microRNA-200a (miR-200a) is frequently downregulated in cancer, its role in side population (SP) has not been investigated. In this study, 101 pairs of primary hepatocellular carcinoma (HCC) tissues and matched normal control tissues were analyzed for miR-200a expression and its clinicopathological value was determined. We found that miR-200a was downregulated in HCC/SP and this was associated metastasis. MiR-200a suppressed metastasis of SP cells. Overexpression of miR-200a in SP cells decreased metastasis-related markers and expression of ZEB2. The associations between miR-200a, SP cells and ZEB2 were validated in HCC. These findings reveal that miR-200a suppresses metastasis of SP cells by downregulating ZEB2.
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spelling pubmed-44807252015-06-26 MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2 Yang, Xisheng Wang, Jianlin Qu, Shibin Zhang, Hongtao Ruan, Bai Gao, Yuan Ma, Ben Wang, Xing Wu, Nan Li, Xiaolei Dou, Kefeng Li, Haimin Oncotarget Research Paper Although microRNA-200a (miR-200a) is frequently downregulated in cancer, its role in side population (SP) has not been investigated. In this study, 101 pairs of primary hepatocellular carcinoma (HCC) tissues and matched normal control tissues were analyzed for miR-200a expression and its clinicopathological value was determined. We found that miR-200a was downregulated in HCC/SP and this was associated metastasis. MiR-200a suppressed metastasis of SP cells. Overexpression of miR-200a in SP cells decreased metastasis-related markers and expression of ZEB2. The associations between miR-200a, SP cells and ZEB2 were validated in HCC. These findings reveal that miR-200a suppresses metastasis of SP cells by downregulating ZEB2. Impact Journals LLC 2015-03-08 /pmc/articles/PMC4480725/ /pubmed/25797260 Text en Copyright: © 2015 Yang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Yang, Xisheng
Wang, Jianlin
Qu, Shibin
Zhang, Hongtao
Ruan, Bai
Gao, Yuan
Ma, Ben
Wang, Xing
Wu, Nan
Li, Xiaolei
Dou, Kefeng
Li, Haimin
MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2
title MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2
title_full MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2
title_fullStr MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2
title_full_unstemmed MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2
title_short MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2
title_sort microrna-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing zeb2
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480725/
https://www.ncbi.nlm.nih.gov/pubmed/25797260
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