Cargando…

Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells

All-trans retinoic acid (ATRA) is a differentiating agent for the treatment of acute promyelocytic leukemia (APL). However, the therapeutic efficacy of ATRA has limitations. Tetrandrine is a traditional Chinese medicinal herb extract with antitumor effects. In this study, we investigated the effects...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Ting, Men, Qiuxu, Wu, Guixian, Yu, Chunrong, Huang, Zan, Liu, Xin, Li, Wenhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480730/ https://www.ncbi.nlm.nih.gov/pubmed/25797266

Ejemplares similares

c-MYC and reactive oxygen species play roles in tetrandrine-induced leukemia differentiation
por: Wu, Guixian, et al.
Publicado: (2018)

Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species
por: Wang, Haiqing, et al.
Publicado: (2015)

Tetrandrine, a Chinese plant-derived alkaloid, is a potential candidate for cancer chemotherapy
por: Liu, Ting, et al.
Publicado: (2016)

The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells
por: Zhang, Zhenxing, et al.
Publicado: (2018)

Synergistic antitumour activity of sorafenib in combination with tetrandrine is mediated by reactive oxygen species (ROS)/Akt signaling
por: Wan, J, et al.
Publicado: (2013)

Tetrandrine Modulates Rheb-mTOR Signaling-Mediated Selective Autophagy and Protects Pulmonary Fibrosis
por: Liu, Yuanyuan, et al.
Publicado: (2021)

Tetrandrine Inhibits Skeletal Muscle Differentiation by Blocking Autophagic Flux
por: Li, Jing, et al.
Publicado: (2022)

Combination therapy with protein kinase inhibitor H89 and Tetrandrine elicits enhanced synergistic antitumor efficacy
por: Yu, Man, et al.
Publicado: (2018)

Tetrandrine reduces oxidative stress, apoptosis, and extracellular matrix degradation and improves intervertebral disc degeneration by inducing autophagy
por: Liu, Jintao, et al.
Publicado: (2022)

Tetrandrine sensitizes nasopharyngeal carcinoma cells to irradiation by inducing autophagy and inhibiting MEK/ERK pathway
por: Wang, Jun, et al.
Publicado: (2020)

Nuclear localization of TEF3-1 promotes cell cycle progression and angiogenesis in cancer
por: Teng, Kaixuan, et al.
Publicado: (2016)

Tetrandrine suppresses the growth of human osteosarcoma cells by regulating multiple signaling pathways
por: Wang, Nan, et al.
Publicado: (2021)

Tetrandrine Derivatives as Promising Antibacterial Agents
por: Calvillo-Páez, Viviana I., et al.
Publicado: (2023)

Tetrandrine Prevents Neomycin-Induced Ototoxicity by Promoting Steroid Biosynthesis
por: Zhang, Qilei, et al.
Publicado: (2022)

Autophagy is involved in mouse kidney development and podocyte differentiation regulated by Notch signalling
por: Zhang, Chuyue, et al.
Publicado: (2017)

MicroRNA-375 overexpression influences P19 cell proliferation, apoptosis and differentiation through the Notch signaling pathway
por: WANG, LIHUA, et al.
Publicado: (2016)

Protective Effect of Tetrandrine on Sodium Taurocholate-Induced Severe Acute Pancreatitis
por: Wu, Xian-lin, et al.
Publicado: (2015)

Tetrandrine Treatment May Improve Clinical Outcome in Patients with COVID-19
por: Chen, Shiyin, et al.
Publicado: (2022)

Enhanced Topical Delivery of Tetrandrine by Ethosomes for Treatment of Arthritis
por: Fan, Chao, et al.
Publicado: (2013)

Notch Signaling in Acute Promyelocytic Leukemia
por: Grieselhuber, Nicole R., et al.
Publicado: (2013)

The emerging roles of Notch signaling in leukemia and stem cells
por: Liu, Na, et al.
Publicado: (2013)

Tetrandrine, an Activator of Autophagy, Induces Autophagic Cell Death via PKC-α Inhibition and mTOR-Dependent Mechanisms
por: Wong, Vincent Kam Wai, et al.
Publicado: (2017)

Effect of Tetrandrine against Candida albicans Biofilms
por: Zhao, Lan-Xue, et al.
Publicado: (2013)

Neuroprotective effects of tetrandrine against vascular dementia
por: Lv, Yan-ling, et al.
Publicado: (2016)

Liquid Crystalline Nanoparticles as an Ophthalmic Delivery System for Tetrandrine: Development, Characterization, and In Vitro and In Vivo Evaluation
por: Liu, Rui, et al.
Publicado: (2016)

Tetrandrine Attenuated Doxorubicin-Induced Acute Cardiac Injury in Mice
por: Li, Gang, et al.
Publicado: (2020)

Tetrandrine inhibits RANKL-induced osteoclastogenesis by promoting the degradation of TRAIL
por: Li, Jiarui, et al.
Publicado: (2022)

Tetrandrine-Induced Autophagy in MDA-MB-231 Triple-Negative Breast Cancer Cell through the Inhibition of PI3K/AKT/mTOR Signaling
por: Guo, Yubo, et al.
Publicado: (2019)

The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia
por: Choi, Sung Hee, et al.
Publicado: (2017)

Progress on structural modification of Tetrandrine with wide range of pharmacological activities
por: Mo, Liuying, et al.
Publicado: (2022)

Tetrandrine attenuates left ventricular dysfunction in rats with myocardial infarction
por: Wu, Youyang, et al.
Publicado: (2021)

Tetrandrine alleviates podocyte injury via calcium-dependent calpain-1 signaling blockade
por: Ding, Yin, et al.
Publicado: (2021)

Photodynamic N-TiO(2) Nanoparticle Treatment Induces Controlled ROS-mediated Autophagy and Terminal Differentiation of Leukemia Cells
por: Moosavi, Mohammad Amin, et al.
Publicado: (2016)

Tetrandrine Ameliorates Rheumatoid Arthritis in Mice by Alleviating Neutrophil Activities
por: Lu, Qingyi, et al.
Publicado: (2022)

The Potential of Tetrandrine as a Protective Agent for Ischemic Stroke
por: Chen, Yun, et al.
Publicado: (2011)

Synthesis, biological evaluation and toxicity of novel tetrandrine analogues
por: Schütz, Ramona, et al.
Publicado: (2020)

Tetrandrine suppresses proliferation, induces apoptosis, and inhibits migration and invasion in human prostate cancer cells
por: Liu, Wei, et al.
Publicado: (2015)

Mediation of Endogenous β-endorphin by Tetrandrine to Lower Plasma Glucose in Streptozotocin-induced Diabetic Rats
por: Hsu, Jen-Hao, et al.
Publicado: (2004)

Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia
por: Ye, Qi, et al.
Publicado: (2016)

Tetrandrine suppresses cervical cancer growth by inducing apoptosis in vitro and in vivo
por: Zhang, Haiyan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ann0q3hm0slf5pcsd0332mako7