Ndrg2 promoter hypermethylation triggered by helicobacter pylori infection correlates with poor patients survival in human gastric carcinoma

N-myc downstream regulated gene 2 (Ndrg2) is a candidate suppressor of cancer metastasis. We found that Ndrg2 promoter was frequently hypermethylated in gastric cancer cell lines and in 292 gastric tumor tissues. This resulted in down-regulation of Ndrg2 mRNA and protein. Ndrg2 promoter methylation...

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Autores principales: Ling, Zhi-Qiang, Ge, Ming-Hua, Lu, Xiao-Xiao, Han, Jin, Wu, Yi-Chen, Liu, Xiang, Zhu, Xin, Hong, Lian-Lian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480746/
https://www.ncbi.nlm.nih.gov/pubmed/25823664
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author Ling, Zhi-Qiang
Ge, Ming-Hua
Lu, Xiao-Xiao
Han, Jin
Wu, Yi-Chen
Liu, Xiang
Zhu, Xin
Hong, Lian-Lian
author_facet Ling, Zhi-Qiang
Ge, Ming-Hua
Lu, Xiao-Xiao
Han, Jin
Wu, Yi-Chen
Liu, Xiang
Zhu, Xin
Hong, Lian-Lian
author_sort Ling, Zhi-Qiang
collection PubMed
description N-myc downstream regulated gene 2 (Ndrg2) is a candidate suppressor of cancer metastasis. We found that Ndrg2 promoter was frequently hypermethylated in gastric cancer cell lines and in 292 gastric tumor tissues. This resulted in down-regulation of Ndrg2 mRNA and protein. Ndrg2 promoter methylation was associated with H. pylori infection and worse prognosis of gastric cancer patients, which is an independent prognostic factor for the disease-free survival (DFS). We found that H. pylori silenced Ndrg2 by activating the NF-κB pathway and up-regulating DNMT3b, promoting gastric cancer progression. These findings uncover a previously unrecognized role for H. pylori infection in gastric cancer.
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spelling pubmed-44807462015-06-26 Ndrg2 promoter hypermethylation triggered by helicobacter pylori infection correlates with poor patients survival in human gastric carcinoma Ling, Zhi-Qiang Ge, Ming-Hua Lu, Xiao-Xiao Han, Jin Wu, Yi-Chen Liu, Xiang Zhu, Xin Hong, Lian-Lian Oncotarget Research Paper N-myc downstream regulated gene 2 (Ndrg2) is a candidate suppressor of cancer metastasis. We found that Ndrg2 promoter was frequently hypermethylated in gastric cancer cell lines and in 292 gastric tumor tissues. This resulted in down-regulation of Ndrg2 mRNA and protein. Ndrg2 promoter methylation was associated with H. pylori infection and worse prognosis of gastric cancer patients, which is an independent prognostic factor for the disease-free survival (DFS). We found that H. pylori silenced Ndrg2 by activating the NF-κB pathway and up-regulating DNMT3b, promoting gastric cancer progression. These findings uncover a previously unrecognized role for H. pylori infection in gastric cancer. Impact Journals LLC 2015-03-15 /pmc/articles/PMC4480746/ /pubmed/25823664 Text en Copyright: © 2015 Ling et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Ling, Zhi-Qiang
Ge, Ming-Hua
Lu, Xiao-Xiao
Han, Jin
Wu, Yi-Chen
Liu, Xiang
Zhu, Xin
Hong, Lian-Lian
Ndrg2 promoter hypermethylation triggered by helicobacter pylori infection correlates with poor patients survival in human gastric carcinoma
title Ndrg2 promoter hypermethylation triggered by helicobacter pylori infection correlates with poor patients survival in human gastric carcinoma
title_full Ndrg2 promoter hypermethylation triggered by helicobacter pylori infection correlates with poor patients survival in human gastric carcinoma
title_fullStr Ndrg2 promoter hypermethylation triggered by helicobacter pylori infection correlates with poor patients survival in human gastric carcinoma
title_full_unstemmed Ndrg2 promoter hypermethylation triggered by helicobacter pylori infection correlates with poor patients survival in human gastric carcinoma
title_short Ndrg2 promoter hypermethylation triggered by helicobacter pylori infection correlates with poor patients survival in human gastric carcinoma
title_sort ndrg2 promoter hypermethylation triggered by helicobacter pylori infection correlates with poor patients survival in human gastric carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480746/
https://www.ncbi.nlm.nih.gov/pubmed/25823664
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