Ndrg2 promoter hypermethylation triggered by helicobacter pylori infection correlates with poor patients survival in human gastric carcinoma

N-myc downstream regulated gene 2 (Ndrg2) is a candidate suppressor of cancer metastasis. We found that Ndrg2 promoter was frequently hypermethylated in gastric cancer cell lines and in 292 gastric tumor tissues. This resulted in down-regulation of Ndrg2 mRNA and protein. Ndrg2 promoter methylation...

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Detalles Bibliográficos
Autores principales: Ling, Zhi-Qiang, Ge, Ming-Hua, Lu, Xiao-Xiao, Han, Jin, Wu, Yi-Chen, Liu, Xiang, Zhu, Xin, Hong, Lian-Lian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480746/
https://www.ncbi.nlm.nih.gov/pubmed/25823664

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