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MLH1 V384D polymorphism associates with poor response to EGFR tyrosine kinase inhibitors in patients with EGFR L858R-positive lung adenocarcinoma

A significant fraction of patients with lung adenocarcinomas harboring activating epidermal growth factor receptor (EGFR) mutations do not experience clinical benefits from EGFR tyrosine kinase inhibitor (TKI) therapy. Using next-generation sequencing, we screened 739 mutation hotspots in 46 cancer-...

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Detalles Bibliográficos
Autores principales:	Chiu, Chao-Hua, Ho, Hsiang-Ling, Doong, Howard, Yeh, Yi-Chen, Chen, Mei-Yu, Chou, Teh-Ying, Tsai, Chun-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Clinical Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480762/ https://www.ncbi.nlm.nih.gov/pubmed/25823662

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