Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3

TLR2 promotes NLRP3 inflammasome activation via an early MyD88-IRAK1-dependent pathway that provides a priming signal (signal 1) necessary for activation of the inflammasome by a second potassium-depleting signal (signal 2). Here we show that TLR3 binding to dsRNA promotes post-translational inflamm...

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Detalles Bibliográficos
Autores principales: Kang, Seokwon, Fernandes-Alnemri, Teresa, Rogers, Corey, Mayes, Lindsey, Wang, Ying, Dillon, Christopher, Roback, Linda, Kaiser, William, Oberst, Andrew, Sagara, Junji, Fitzgerald, Katherine A., Green, Douglas R., Zhang, Jianke, Mocarski, Edward S., Alnemri, Emad S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480782/
https://www.ncbi.nlm.nih.gov/pubmed/26104484
http://dx.doi.org/10.1038/ncomms8515

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