SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing

BACKGROUND: SIRT1 is likely to play a role in the extension in healthspan induced by dietary restriction. Actions of SIRT1 are pleiotropic, and effects on healthspan may include effects on DNA methylation. Polycomb group protein target genes (PCGTs) are suppressed by epigenetic mechanisms in stem ce...

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Detalles Bibliográficos
Autores principales: Wakeling, Luisa A, Ions, Laura J, Escolme, Suzanne M, Cockell, Simon J, Su, Tianhong, Dey, Madhurima, Hampton, Emily V, Jenkins, Gail, Wainwright, Linda J, McKay, Jill A, Ford, Dianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480908/
https://www.ncbi.nlm.nih.gov/pubmed/26104761
http://dx.doi.org/10.1186/s40246-015-0036-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480908/
https://www.ncbi.nlm.nih.gov/pubmed/26104761
http://dx.doi.org/10.1186/s40246-015-0036-0

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