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Interaction between the Haptoglobin 2 Phenotype and Diabetes Mellitus on Systolic Pulmonary Arterial Pressure and Nitric Oxide Bioavailability in Hemodialysis Patients

Elevated systolic pulmonary artery pressure (s-PAP, ≥35 mmHg) serves as an independent predictor of mortality in hemodialysis (HD) and diabetic (DM) patients. A polymorphism in the antioxidant Haptoglobin (Hp) gene has been shown to regulate the bioavailability of nitric oxide (NO), a major mediator...

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Autores principales: Dahan, Inbal, Farber, Evgeny, Thauho, Nadia, Nakhoul, Nakhoul, Francis, Adi, Awawde, Mohamad, Levy, Andrew P., Kim-Shapiro, Daniel B., Basu, Swati, Nakhoul, Farid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481085/
https://www.ncbi.nlm.nih.gov/pubmed/26171400
http://dx.doi.org/10.1155/2015/613860
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author Dahan, Inbal
Farber, Evgeny
Thauho, Nadia
Nakhoul, Nakhoul
Francis, Adi
Awawde, Mohamad
Levy, Andrew P.
Kim-Shapiro, Daniel B.
Basu, Swati
Nakhoul, Farid
author_facet Dahan, Inbal
Farber, Evgeny
Thauho, Nadia
Nakhoul, Nakhoul
Francis, Adi
Awawde, Mohamad
Levy, Andrew P.
Kim-Shapiro, Daniel B.
Basu, Swati
Nakhoul, Farid
author_sort Dahan, Inbal
collection PubMed
description Elevated systolic pulmonary artery pressure (s-PAP, ≥35 mmHg) serves as an independent predictor of mortality in hemodialysis (HD) and diabetic (DM) patients. A polymorphism in the antioxidant Haptoglobin (Hp) gene has been shown to regulate the bioavailability of nitric oxide (NO), a major mediator of pulmonary vascular tone. We therefore set out to test the hypothesis that the Hp polymorphism may be a determinant of developing elevated s-PAP specifically in the DM state due to a decreased bioavailability of NO. To test our hypothesis we Hp typed and performed transthoracic echocardiography on a series of HD patients and stratified them into elevated and normal s-PAP groups and then evaluated whether there was a significant association between the Hp type, elevated s-PAP, and decreased NO bioavailability as defined by low plasma nitrite. We found a statistically significant interaction between the Hp type and DM on the prevalence of elevated s-PAP and lower mean nitrite levels with the combination of elevated s-PAP and low nitrite levels being significantly more prevalent in Hp 2-2 DM individuals. We conclude that the Hp 2 type is associated with elevated s-PAP levels and low plasma nitrite levels in HD patients specifically in the DM state.
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spelling pubmed-44810852015-07-13 Interaction between the Haptoglobin 2 Phenotype and Diabetes Mellitus on Systolic Pulmonary Arterial Pressure and Nitric Oxide Bioavailability in Hemodialysis Patients Dahan, Inbal Farber, Evgeny Thauho, Nadia Nakhoul, Nakhoul Francis, Adi Awawde, Mohamad Levy, Andrew P. Kim-Shapiro, Daniel B. Basu, Swati Nakhoul, Farid J Diabetes Res Clinical Study Elevated systolic pulmonary artery pressure (s-PAP, ≥35 mmHg) serves as an independent predictor of mortality in hemodialysis (HD) and diabetic (DM) patients. A polymorphism in the antioxidant Haptoglobin (Hp) gene has been shown to regulate the bioavailability of nitric oxide (NO), a major mediator of pulmonary vascular tone. We therefore set out to test the hypothesis that the Hp polymorphism may be a determinant of developing elevated s-PAP specifically in the DM state due to a decreased bioavailability of NO. To test our hypothesis we Hp typed and performed transthoracic echocardiography on a series of HD patients and stratified them into elevated and normal s-PAP groups and then evaluated whether there was a significant association between the Hp type, elevated s-PAP, and decreased NO bioavailability as defined by low plasma nitrite. We found a statistically significant interaction between the Hp type and DM on the prevalence of elevated s-PAP and lower mean nitrite levels with the combination of elevated s-PAP and low nitrite levels being significantly more prevalent in Hp 2-2 DM individuals. We conclude that the Hp 2 type is associated with elevated s-PAP levels and low plasma nitrite levels in HD patients specifically in the DM state. Hindawi Publishing Corporation 2015 2015-06-11 /pmc/articles/PMC4481085/ /pubmed/26171400 http://dx.doi.org/10.1155/2015/613860 Text en Copyright © 2015 Inbal Dahan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Dahan, Inbal
Farber, Evgeny
Thauho, Nadia
Nakhoul, Nakhoul
Francis, Adi
Awawde, Mohamad
Levy, Andrew P.
Kim-Shapiro, Daniel B.
Basu, Swati
Nakhoul, Farid
Interaction between the Haptoglobin 2 Phenotype and Diabetes Mellitus on Systolic Pulmonary Arterial Pressure and Nitric Oxide Bioavailability in Hemodialysis Patients
title Interaction between the Haptoglobin 2 Phenotype and Diabetes Mellitus on Systolic Pulmonary Arterial Pressure and Nitric Oxide Bioavailability in Hemodialysis Patients
title_full Interaction between the Haptoglobin 2 Phenotype and Diabetes Mellitus on Systolic Pulmonary Arterial Pressure and Nitric Oxide Bioavailability in Hemodialysis Patients
title_fullStr Interaction between the Haptoglobin 2 Phenotype and Diabetes Mellitus on Systolic Pulmonary Arterial Pressure and Nitric Oxide Bioavailability in Hemodialysis Patients
title_full_unstemmed Interaction between the Haptoglobin 2 Phenotype and Diabetes Mellitus on Systolic Pulmonary Arterial Pressure and Nitric Oxide Bioavailability in Hemodialysis Patients
title_short Interaction between the Haptoglobin 2 Phenotype and Diabetes Mellitus on Systolic Pulmonary Arterial Pressure and Nitric Oxide Bioavailability in Hemodialysis Patients
title_sort interaction between the haptoglobin 2 phenotype and diabetes mellitus on systolic pulmonary arterial pressure and nitric oxide bioavailability in hemodialysis patients
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481085/
https://www.ncbi.nlm.nih.gov/pubmed/26171400
http://dx.doi.org/10.1155/2015/613860
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