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HLA-DRα1-mMOG-35-55 treatment of experimental autoimmune encephalomyelitis reduces CNS inflammation, enhances M2 macrophage frequency, and promotes neuroprotection

BACKGROUND: DRα1-mouse(m)MOG-35-55, a novel construct developed in our laboratory as a simpler and potentially less immunogenic alternative to two-domain class II constructs, was shown previously to target the MIF/CD74 pathway and to reverse clinical and histological signs of experimental autoimmune...

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Detalles Bibliográficos
Autores principales:	Benedek, Gil, Meza-Romero, Roberto, Jordan, Kelley, Keenlyside, Lucy, Offner, Halina, Vandenbark, Arthur A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481122/ https://www.ncbi.nlm.nih.gov/pubmed/26104759 http://dx.doi.org/10.1186/s12974-015-0342-4

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