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Disruption of gut homeostasis by opioids accelerates HIV disease progression

Cumulative studies during the past 30 years have established the correlation between opioid abuse and human immunodeficiency virus (HIV) infection. Further studies also demonstrate that opioid addiction is associated with faster progression to AIDS in patients. Recently, it was revealed that disrupt...

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Detalles Bibliográficos
Autores principales: Meng, Jingjing, Sindberg, Gregory M., Roy, Sabita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481162/
https://www.ncbi.nlm.nih.gov/pubmed/26167159
http://dx.doi.org/10.3389/fmicb.2015.00643
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author Meng, Jingjing
Sindberg, Gregory M.
Roy, Sabita
author_facet Meng, Jingjing
Sindberg, Gregory M.
Roy, Sabita
author_sort Meng, Jingjing
collection PubMed
description Cumulative studies during the past 30 years have established the correlation between opioid abuse and human immunodeficiency virus (HIV) infection. Further studies also demonstrate that opioid addiction is associated with faster progression to AIDS in patients. Recently, it was revealed that disruption of gut homeostasis and subsequent microbial translocation play important roles in pathological activation of the immune system during HIV infection and contributes to accelerated disease progression. Similarly, opioids have been shown to modulate gut immunity and induce gut bacterial translocation. This review will explore the mechanisms by which opioids accelerate HIV disease progression by disrupting gut homeostasis. Better understanding of these mechanisms will facilitate the search for new therapeutic interventions to treat HIV infection especially in opioid abusing population.
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spelling pubmed-44811622015-07-10 Disruption of gut homeostasis by opioids accelerates HIV disease progression Meng, Jingjing Sindberg, Gregory M. Roy, Sabita Front Microbiol Microbiology Cumulative studies during the past 30 years have established the correlation between opioid abuse and human immunodeficiency virus (HIV) infection. Further studies also demonstrate that opioid addiction is associated with faster progression to AIDS in patients. Recently, it was revealed that disruption of gut homeostasis and subsequent microbial translocation play important roles in pathological activation of the immune system during HIV infection and contributes to accelerated disease progression. Similarly, opioids have been shown to modulate gut immunity and induce gut bacterial translocation. This review will explore the mechanisms by which opioids accelerate HIV disease progression by disrupting gut homeostasis. Better understanding of these mechanisms will facilitate the search for new therapeutic interventions to treat HIV infection especially in opioid abusing population. Frontiers Media S.A. 2015-06-26 /pmc/articles/PMC4481162/ /pubmed/26167159 http://dx.doi.org/10.3389/fmicb.2015.00643 Text en Copyright © 2015 Meng, Sindberg and Roy. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Meng, Jingjing
Sindberg, Gregory M.
Roy, Sabita
Disruption of gut homeostasis by opioids accelerates HIV disease progression
title Disruption of gut homeostasis by opioids accelerates HIV disease progression
title_full Disruption of gut homeostasis by opioids accelerates HIV disease progression
title_fullStr Disruption of gut homeostasis by opioids accelerates HIV disease progression
title_full_unstemmed Disruption of gut homeostasis by opioids accelerates HIV disease progression
title_short Disruption of gut homeostasis by opioids accelerates HIV disease progression
title_sort disruption of gut homeostasis by opioids accelerates hiv disease progression
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481162/
https://www.ncbi.nlm.nih.gov/pubmed/26167159
http://dx.doi.org/10.3389/fmicb.2015.00643
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