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Cytotoxic T lymphocyte antigen 4 expression in human breast cancer: implications for prognosis
To examine the relationship between cytotoxic T lymphocyte antigen 4 (CTLA-4) expression and breast cancer prognosis, CTLA-4 expression was immunohistochemically detected in paraffin-embedded specimens of primary tumors from 130 patients with breast cancer who had a mean follow-up period of 112 mont...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481300/ https://www.ncbi.nlm.nih.gov/pubmed/25893809 http://dx.doi.org/10.1007/s00262-015-1696-2 |
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author | Yu, Haiming Yang, Junlan Jiao, Shunchang Li, Ying Zhang, Wei Wang, Jiandong |
author_facet | Yu, Haiming Yang, Junlan Jiao, Shunchang Li, Ying Zhang, Wei Wang, Jiandong |
author_sort | Yu, Haiming |
collection | PubMed |
description | To examine the relationship between cytotoxic T lymphocyte antigen 4 (CTLA-4) expression and breast cancer prognosis, CTLA-4 expression was immunohistochemically detected in paraffin-embedded specimens of primary tumors from 130 patients with breast cancer who had a mean follow-up period of 112 months. CTLA-4 expressed in cytoplasm of breast cancer cells and in cytoplasm and cell membranes of interstitial lymphocytes. Univariate analysis (log-rank) associated higher density of interstitial CTLA-4(+) lymphocytes with longer DFS and OS, but higher tumor CTLA-4 expression with shorter OS. After controlling for age, clinical stage, Scarff-Bloom-Richardson grade, tumor thrombus, ER, PR, HER2 and Ki-67, multivariate analysis (Cox) showed that density of interstitial CTLA-4(+) lymphocytes independently predicted longer DFS (HR 0.315, P = 0.002) and OS (HR 0.313, P = 0.005), whereas tumor CTLA-4 expression independently predicted shorter DFS (HR 2.176, P = 0.029) and OS (HR 2.820, P = 0.007), i.e., patients with high CTLA-4(+) lymphocyte density and CTLA-4(low) tumor cells had the best prognoses. These results indicated that CTLA-4 expression in lymphocytes was associated with better prognosis, but that in tumor cells was associated with worse prognosis. Patients’ CTLA-4 profiles might thus be used to predict the benefits and toxicity of CTLA-4 blockade. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00262-015-1696-2) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4481300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-44813002015-07-02 Cytotoxic T lymphocyte antigen 4 expression in human breast cancer: implications for prognosis Yu, Haiming Yang, Junlan Jiao, Shunchang Li, Ying Zhang, Wei Wang, Jiandong Cancer Immunol Immunother Original Article To examine the relationship between cytotoxic T lymphocyte antigen 4 (CTLA-4) expression and breast cancer prognosis, CTLA-4 expression was immunohistochemically detected in paraffin-embedded specimens of primary tumors from 130 patients with breast cancer who had a mean follow-up period of 112 months. CTLA-4 expressed in cytoplasm of breast cancer cells and in cytoplasm and cell membranes of interstitial lymphocytes. Univariate analysis (log-rank) associated higher density of interstitial CTLA-4(+) lymphocytes with longer DFS and OS, but higher tumor CTLA-4 expression with shorter OS. After controlling for age, clinical stage, Scarff-Bloom-Richardson grade, tumor thrombus, ER, PR, HER2 and Ki-67, multivariate analysis (Cox) showed that density of interstitial CTLA-4(+) lymphocytes independently predicted longer DFS (HR 0.315, P = 0.002) and OS (HR 0.313, P = 0.005), whereas tumor CTLA-4 expression independently predicted shorter DFS (HR 2.176, P = 0.029) and OS (HR 2.820, P = 0.007), i.e., patients with high CTLA-4(+) lymphocyte density and CTLA-4(low) tumor cells had the best prognoses. These results indicated that CTLA-4 expression in lymphocytes was associated with better prognosis, but that in tumor cells was associated with worse prognosis. Patients’ CTLA-4 profiles might thus be used to predict the benefits and toxicity of CTLA-4 blockade. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00262-015-1696-2) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2015-04-17 2015 /pmc/articles/PMC4481300/ /pubmed/25893809 http://dx.doi.org/10.1007/s00262-015-1696-2 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Yu, Haiming Yang, Junlan Jiao, Shunchang Li, Ying Zhang, Wei Wang, Jiandong Cytotoxic T lymphocyte antigen 4 expression in human breast cancer: implications for prognosis |
title | Cytotoxic T lymphocyte antigen 4 expression in human breast cancer: implications for prognosis |
title_full | Cytotoxic T lymphocyte antigen 4 expression in human breast cancer: implications for prognosis |
title_fullStr | Cytotoxic T lymphocyte antigen 4 expression in human breast cancer: implications for prognosis |
title_full_unstemmed | Cytotoxic T lymphocyte antigen 4 expression in human breast cancer: implications for prognosis |
title_short | Cytotoxic T lymphocyte antigen 4 expression in human breast cancer: implications for prognosis |
title_sort | cytotoxic t lymphocyte antigen 4 expression in human breast cancer: implications for prognosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481300/ https://www.ncbi.nlm.nih.gov/pubmed/25893809 http://dx.doi.org/10.1007/s00262-015-1696-2 |
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