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Cytotoxic T lymphocyte antigen 4 expression in human breast cancer: implications for prognosis

To examine the relationship between cytotoxic T lymphocyte antigen 4 (CTLA-4) expression and breast cancer prognosis, CTLA-4 expression was immunohistochemically detected in paraffin-embedded specimens of primary tumors from 130 patients with breast cancer who had a mean follow-up period of 112 mont...

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Autores principales: Yu, Haiming, Yang, Junlan, Jiao, Shunchang, Li, Ying, Zhang, Wei, Wang, Jiandong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481300/
https://www.ncbi.nlm.nih.gov/pubmed/25893809
http://dx.doi.org/10.1007/s00262-015-1696-2
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author Yu, Haiming
Yang, Junlan
Jiao, Shunchang
Li, Ying
Zhang, Wei
Wang, Jiandong
author_facet Yu, Haiming
Yang, Junlan
Jiao, Shunchang
Li, Ying
Zhang, Wei
Wang, Jiandong
author_sort Yu, Haiming
collection PubMed
description To examine the relationship between cytotoxic T lymphocyte antigen 4 (CTLA-4) expression and breast cancer prognosis, CTLA-4 expression was immunohistochemically detected in paraffin-embedded specimens of primary tumors from 130 patients with breast cancer who had a mean follow-up period of 112 months. CTLA-4 expressed in cytoplasm of breast cancer cells and in cytoplasm and cell membranes of interstitial lymphocytes. Univariate analysis (log-rank) associated higher density of interstitial CTLA-4(+) lymphocytes with longer DFS and OS, but higher tumor CTLA-4 expression with shorter OS. After controlling for age, clinical stage, Scarff-Bloom-Richardson grade, tumor thrombus, ER, PR, HER2 and Ki-67, multivariate analysis (Cox) showed that density of interstitial CTLA-4(+) lymphocytes independently predicted longer DFS (HR 0.315, P = 0.002) and OS (HR 0.313, P = 0.005), whereas tumor CTLA-4 expression independently predicted shorter DFS (HR 2.176, P = 0.029) and OS (HR 2.820, P = 0.007), i.e., patients with high CTLA-4(+) lymphocyte density and CTLA-4(low) tumor cells had the best prognoses. These results indicated that CTLA-4 expression in lymphocytes was associated with better prognosis, but that in tumor cells was associated with worse prognosis. Patients’ CTLA-4 profiles might thus be used to predict the benefits and toxicity of CTLA-4 blockade. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00262-015-1696-2) contains supplementary material, which is available to authorized users.
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spelling pubmed-44813002015-07-02 Cytotoxic T lymphocyte antigen 4 expression in human breast cancer: implications for prognosis Yu, Haiming Yang, Junlan Jiao, Shunchang Li, Ying Zhang, Wei Wang, Jiandong Cancer Immunol Immunother Original Article To examine the relationship between cytotoxic T lymphocyte antigen 4 (CTLA-4) expression and breast cancer prognosis, CTLA-4 expression was immunohistochemically detected in paraffin-embedded specimens of primary tumors from 130 patients with breast cancer who had a mean follow-up period of 112 months. CTLA-4 expressed in cytoplasm of breast cancer cells and in cytoplasm and cell membranes of interstitial lymphocytes. Univariate analysis (log-rank) associated higher density of interstitial CTLA-4(+) lymphocytes with longer DFS and OS, but higher tumor CTLA-4 expression with shorter OS. After controlling for age, clinical stage, Scarff-Bloom-Richardson grade, tumor thrombus, ER, PR, HER2 and Ki-67, multivariate analysis (Cox) showed that density of interstitial CTLA-4(+) lymphocytes independently predicted longer DFS (HR 0.315, P = 0.002) and OS (HR 0.313, P = 0.005), whereas tumor CTLA-4 expression independently predicted shorter DFS (HR 2.176, P = 0.029) and OS (HR 2.820, P = 0.007), i.e., patients with high CTLA-4(+) lymphocyte density and CTLA-4(low) tumor cells had the best prognoses. These results indicated that CTLA-4 expression in lymphocytes was associated with better prognosis, but that in tumor cells was associated with worse prognosis. Patients’ CTLA-4 profiles might thus be used to predict the benefits and toxicity of CTLA-4 blockade. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00262-015-1696-2) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2015-04-17 2015 /pmc/articles/PMC4481300/ /pubmed/25893809 http://dx.doi.org/10.1007/s00262-015-1696-2 Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Yu, Haiming
Yang, Junlan
Jiao, Shunchang
Li, Ying
Zhang, Wei
Wang, Jiandong
Cytotoxic T lymphocyte antigen 4 expression in human breast cancer: implications for prognosis
title Cytotoxic T lymphocyte antigen 4 expression in human breast cancer: implications for prognosis
title_full Cytotoxic T lymphocyte antigen 4 expression in human breast cancer: implications for prognosis
title_fullStr Cytotoxic T lymphocyte antigen 4 expression in human breast cancer: implications for prognosis
title_full_unstemmed Cytotoxic T lymphocyte antigen 4 expression in human breast cancer: implications for prognosis
title_short Cytotoxic T lymphocyte antigen 4 expression in human breast cancer: implications for prognosis
title_sort cytotoxic t lymphocyte antigen 4 expression in human breast cancer: implications for prognosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481300/
https://www.ncbi.nlm.nih.gov/pubmed/25893809
http://dx.doi.org/10.1007/s00262-015-1696-2
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