Sodium glucose transporter 2 (SGLT2) inhibition and ketogenesis

Sodium glucose transporter 2 (SGLT2) inhibitors are a recently developed class of drug that have been approved for use in type 2 diabetes. Their unique extra-pancreatic glucuretic mode of action has encouraged their usage in type 1 diabetes as well. At the same time, reports of pseudo ketoacidosis a...

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Detalles Bibliográficos
Autores principales: Kalra, Sanjay, Sahay, Rakesh, Gupta, Yashdeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481661/
https://www.ncbi.nlm.nih.gov/pubmed/26180770
http://dx.doi.org/10.4103/2230-8210.157859
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author Kalra, Sanjay
Sahay, Rakesh
Gupta, Yashdeep
author_facet Kalra, Sanjay
Sahay, Rakesh
Gupta, Yashdeep
author_sort Kalra, Sanjay
collection PubMed
description Sodium glucose transporter 2 (SGLT2) inhibitors are a recently developed class of drug that have been approved for use in type 2 diabetes. Their unique extra-pancreatic glucuretic mode of action has encouraged their usage in type 1 diabetes as well. At the same time, reports of pseudo ketoacidosis and ketoacidosis related to their use have been published. No clear mechanism for this phenomenon has been demonstrated so far. This communication delves into the biochemical effects of SGLT2 inhibition, discusses the utility of these drugs and proposes steps to maximize safe usage of the molecules.
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spelling pubmed-44816612015-07-15 Sodium glucose transporter 2 (SGLT2) inhibition and ketogenesis Kalra, Sanjay Sahay, Rakesh Gupta, Yashdeep Indian J Endocrinol Metab Brief Communication Sodium glucose transporter 2 (SGLT2) inhibitors are a recently developed class of drug that have been approved for use in type 2 diabetes. Their unique extra-pancreatic glucuretic mode of action has encouraged their usage in type 1 diabetes as well. At the same time, reports of pseudo ketoacidosis and ketoacidosis related to their use have been published. No clear mechanism for this phenomenon has been demonstrated so far. This communication delves into the biochemical effects of SGLT2 inhibition, discusses the utility of these drugs and proposes steps to maximize safe usage of the molecules. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4481661/ /pubmed/26180770 http://dx.doi.org/10.4103/2230-8210.157859 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Brief Communication
Kalra, Sanjay
Sahay, Rakesh
Gupta, Yashdeep
Sodium glucose transporter 2 (SGLT2) inhibition and ketogenesis
title Sodium glucose transporter 2 (SGLT2) inhibition and ketogenesis
title_full Sodium glucose transporter 2 (SGLT2) inhibition and ketogenesis
title_fullStr Sodium glucose transporter 2 (SGLT2) inhibition and ketogenesis
title_full_unstemmed Sodium glucose transporter 2 (SGLT2) inhibition and ketogenesis
title_short Sodium glucose transporter 2 (SGLT2) inhibition and ketogenesis
title_sort sodium glucose transporter 2 (sglt2) inhibition and ketogenesis
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481661/
https://www.ncbi.nlm.nih.gov/pubmed/26180770
http://dx.doi.org/10.4103/2230-8210.157859
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AT guptayashdeep sodiumglucosetransporter2sglt2inhibitionandketogenesis

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