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Hypercoagulability in hereditary hemorrhagic telangiectasia with epilepsy
Recent data indicate that in patients with hereditary hemorrhagic teleangiectasia (HHT), low iron levels due to inadequate replacement after hemorrhagic iron losses are associated with elevated factor-VIII plasma levels and consecutively increased risk of venous thrombo-embolism. Here, we report a p...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481800/ https://www.ncbi.nlm.nih.gov/pubmed/26167029 http://dx.doi.org/10.4103/0976-3147.158791 |
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author | Finsterer, Josef Sehnal, Ernst |
author_facet | Finsterer, Josef Sehnal, Ernst |
author_sort | Finsterer, Josef |
collection | PubMed |
description | Recent data indicate that in patients with hereditary hemorrhagic teleangiectasia (HHT), low iron levels due to inadequate replacement after hemorrhagic iron losses are associated with elevated factor-VIII plasma levels and consecutively increased risk of venous thrombo-embolism. Here, we report a patient with HHT, low iron levels, elevated factor-VIII, and recurrent venous thrombo-embolism. A 64-year-old multimorbid Serbian gipsy was diagnosed with HHT at age 62 years. He had a history of recurrent epistaxis, teleangiectasias on the lips, renal and pulmonary arterio-venous malformations, and a family history positive for HHT. He had experienced recurrent venous thrombosis (mesenteric vein thrombosis, portal venous thrombosis, deep venous thrombosis), insufficiently treated with phenprocoumon during 16 months and gastro-intestinal bleeding. Blood tests revealed sideropenia and elevated plasma levels of coagulation factor-VIII. His history was positive for diabetes, arterial hypertension, hyperlipidemia, smoking, cerebral abscess, recurrent ischemic stroke, recurrent ileus, peripheral arterial occluding disease, polyneuropathy, mild renal insufficiency, and epilepsy. Following recent findings, hypercoagulability was attributed to the sideropenia-induced elevation of coagulation factor-VIII. In conclusion, HHT may be associated with hypercoagulability due to elevated factor-VIII associated with low serum iron levels from recurrent bleeding. Iron substitution may prevent HHT patients from hypercoagulability. |
format | Online Article Text |
id | pubmed-4481800 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-44818002015-07-12 Hypercoagulability in hereditary hemorrhagic telangiectasia with epilepsy Finsterer, Josef Sehnal, Ernst J Neurosci Rural Pract Case Report Recent data indicate that in patients with hereditary hemorrhagic teleangiectasia (HHT), low iron levels due to inadequate replacement after hemorrhagic iron losses are associated with elevated factor-VIII plasma levels and consecutively increased risk of venous thrombo-embolism. Here, we report a patient with HHT, low iron levels, elevated factor-VIII, and recurrent venous thrombo-embolism. A 64-year-old multimorbid Serbian gipsy was diagnosed with HHT at age 62 years. He had a history of recurrent epistaxis, teleangiectasias on the lips, renal and pulmonary arterio-venous malformations, and a family history positive for HHT. He had experienced recurrent venous thrombosis (mesenteric vein thrombosis, portal venous thrombosis, deep venous thrombosis), insufficiently treated with phenprocoumon during 16 months and gastro-intestinal bleeding. Blood tests revealed sideropenia and elevated plasma levels of coagulation factor-VIII. His history was positive for diabetes, arterial hypertension, hyperlipidemia, smoking, cerebral abscess, recurrent ischemic stroke, recurrent ileus, peripheral arterial occluding disease, polyneuropathy, mild renal insufficiency, and epilepsy. Following recent findings, hypercoagulability was attributed to the sideropenia-induced elevation of coagulation factor-VIII. In conclusion, HHT may be associated with hypercoagulability due to elevated factor-VIII associated with low serum iron levels from recurrent bleeding. Iron substitution may prevent HHT patients from hypercoagulability. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4481800/ /pubmed/26167029 http://dx.doi.org/10.4103/0976-3147.158791 Text en Copyright: © Journal of Neurosciences in Rural Practice http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Finsterer, Josef Sehnal, Ernst Hypercoagulability in hereditary hemorrhagic telangiectasia with epilepsy |
title | Hypercoagulability in hereditary hemorrhagic telangiectasia with epilepsy |
title_full | Hypercoagulability in hereditary hemorrhagic telangiectasia with epilepsy |
title_fullStr | Hypercoagulability in hereditary hemorrhagic telangiectasia with epilepsy |
title_full_unstemmed | Hypercoagulability in hereditary hemorrhagic telangiectasia with epilepsy |
title_short | Hypercoagulability in hereditary hemorrhagic telangiectasia with epilepsy |
title_sort | hypercoagulability in hereditary hemorrhagic telangiectasia with epilepsy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481800/ https://www.ncbi.nlm.nih.gov/pubmed/26167029 http://dx.doi.org/10.4103/0976-3147.158791 |
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