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The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17
The metalloproteinase ADAM17 activates ErbB signalling by releasing ligands from the cell surface, a key step underlying epithelial development, growth, and tumour progression. However, mechanisms acutely controlling ADAM17 cell-surface availability to modulate the extent of ErbB ligand release are...
Autores principales: | Dombernowsky, Sarah Louise, Samsøe-Petersen, Jacob, Petersen, Camilla Hansson, Instrell, Rachael, Hedegaard, Anne-Mette Bornhardt, Thomas, Laurel, Atkins, Katelyn Mae, Auclair, Sylvain, Albrechtsen, Reidar, Mygind, Kasper Johansen, Fröhlich, Camilla, Howell, Michael, Parker, Peter, Thomas, Gary, Kveiborg, Marie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481878/ https://www.ncbi.nlm.nih.gov/pubmed/26108729 http://dx.doi.org/10.1038/ncomms8518 |
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