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Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications

Surface plasmon resonance (SPR) is a label-free detection method which has emerged during the last two decades as a suitable and reliable platform in clinical analysis for biomolecular interactions. The technique makes it possible to measure interactions in real-time with high sensitivity and withou...

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Detalles Bibliográficos
Autores principales: Nguyen, Hoang Hiep, Park, Jeho, Kang, Sebyung, Kim, Moonil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481982/
https://www.ncbi.nlm.nih.gov/pubmed/25951336
http://dx.doi.org/10.3390/s150510481
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author Nguyen, Hoang Hiep
Park, Jeho
Kang, Sebyung
Kim, Moonil
author_facet Nguyen, Hoang Hiep
Park, Jeho
Kang, Sebyung
Kim, Moonil
author_sort Nguyen, Hoang Hiep
collection PubMed
description Surface plasmon resonance (SPR) is a label-free detection method which has emerged during the last two decades as a suitable and reliable platform in clinical analysis for biomolecular interactions. The technique makes it possible to measure interactions in real-time with high sensitivity and without the need of labels. This review article discusses a wide range of applications in optical-based sensors using either surface plasmon resonance (SPR) or surface plasmon resonance imaging (SPRI). Here we summarize the principles, provide examples, and illustrate the utility of SPR and SPRI through example applications from the biomedical, proteomics, genomics and bioengineering fields. In addition, SPR signal amplification strategies and surface functionalization are covered in the review.
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spelling pubmed-44819822015-06-29 Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications Nguyen, Hoang Hiep Park, Jeho Kang, Sebyung Kim, Moonil Sensors (Basel) Review Surface plasmon resonance (SPR) is a label-free detection method which has emerged during the last two decades as a suitable and reliable platform in clinical analysis for biomolecular interactions. The technique makes it possible to measure interactions in real-time with high sensitivity and without the need of labels. This review article discusses a wide range of applications in optical-based sensors using either surface plasmon resonance (SPR) or surface plasmon resonance imaging (SPRI). Here we summarize the principles, provide examples, and illustrate the utility of SPR and SPRI through example applications from the biomedical, proteomics, genomics and bioengineering fields. In addition, SPR signal amplification strategies and surface functionalization are covered in the review. MDPI 2015-05-05 /pmc/articles/PMC4481982/ /pubmed/25951336 http://dx.doi.org/10.3390/s150510481 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nguyen, Hoang Hiep
Park, Jeho
Kang, Sebyung
Kim, Moonil
Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications
title Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications
title_full Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications
title_fullStr Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications
title_full_unstemmed Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications
title_short Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications
title_sort surface plasmon resonance: a versatile technique for biosensor applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481982/
https://www.ncbi.nlm.nih.gov/pubmed/25951336
http://dx.doi.org/10.3390/s150510481
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