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Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications
Surface plasmon resonance (SPR) is a label-free detection method which has emerged during the last two decades as a suitable and reliable platform in clinical analysis for biomolecular interactions. The technique makes it possible to measure interactions in real-time with high sensitivity and withou...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481982/ https://www.ncbi.nlm.nih.gov/pubmed/25951336 http://dx.doi.org/10.3390/s150510481 |
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author | Nguyen, Hoang Hiep Park, Jeho Kang, Sebyung Kim, Moonil |
author_facet | Nguyen, Hoang Hiep Park, Jeho Kang, Sebyung Kim, Moonil |
author_sort | Nguyen, Hoang Hiep |
collection | PubMed |
description | Surface plasmon resonance (SPR) is a label-free detection method which has emerged during the last two decades as a suitable and reliable platform in clinical analysis for biomolecular interactions. The technique makes it possible to measure interactions in real-time with high sensitivity and without the need of labels. This review article discusses a wide range of applications in optical-based sensors using either surface plasmon resonance (SPR) or surface plasmon resonance imaging (SPRI). Here we summarize the principles, provide examples, and illustrate the utility of SPR and SPRI through example applications from the biomedical, proteomics, genomics and bioengineering fields. In addition, SPR signal amplification strategies and surface functionalization are covered in the review. |
format | Online Article Text |
id | pubmed-4481982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-44819822015-06-29 Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications Nguyen, Hoang Hiep Park, Jeho Kang, Sebyung Kim, Moonil Sensors (Basel) Review Surface plasmon resonance (SPR) is a label-free detection method which has emerged during the last two decades as a suitable and reliable platform in clinical analysis for biomolecular interactions. The technique makes it possible to measure interactions in real-time with high sensitivity and without the need of labels. This review article discusses a wide range of applications in optical-based sensors using either surface plasmon resonance (SPR) or surface plasmon resonance imaging (SPRI). Here we summarize the principles, provide examples, and illustrate the utility of SPR and SPRI through example applications from the biomedical, proteomics, genomics and bioengineering fields. In addition, SPR signal amplification strategies and surface functionalization are covered in the review. MDPI 2015-05-05 /pmc/articles/PMC4481982/ /pubmed/25951336 http://dx.doi.org/10.3390/s150510481 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nguyen, Hoang Hiep Park, Jeho Kang, Sebyung Kim, Moonil Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications |
title | Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications |
title_full | Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications |
title_fullStr | Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications |
title_full_unstemmed | Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications |
title_short | Surface Plasmon Resonance: A Versatile Technique for Biosensor Applications |
title_sort | surface plasmon resonance: a versatile technique for biosensor applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481982/ https://www.ncbi.nlm.nih.gov/pubmed/25951336 http://dx.doi.org/10.3390/s150510481 |
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