Quantification of recombinant immunotoxin delivery to solid tumors allows for direct comparison of in vivo and in vitro results

Solid tumors present challenges for delivery of protein therapeutics; current methods cannot quantify the functional effects of these agents. RG7787 (anti-mesothelin recombinant immunotoxin) is highly cytotoxic to pancreatic cancer cell lines, but with limited activity in vivo. To investigate this d...

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Detalles Bibliográficos
Autores principales: Mason-Osann, Emily, Hollevoet, Kevin, Niederfellner, Gerhard, Pastan, Ira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482048/
https://www.ncbi.nlm.nih.gov/pubmed/26111884
http://dx.doi.org/10.1038/srep10832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482048/
https://www.ncbi.nlm.nih.gov/pubmed/26111884
http://dx.doi.org/10.1038/srep10832

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