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Quantification of recombinant immunotoxin delivery to solid tumors allows for direct comparison of in vivo and in vitro results
Solid tumors present challenges for delivery of protein therapeutics; current methods cannot quantify the functional effects of these agents. RG7787 (anti-mesothelin recombinant immunotoxin) is highly cytotoxic to pancreatic cancer cell lines, but with limited activity in vivo. To investigate this d...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482048/ https://www.ncbi.nlm.nih.gov/pubmed/26111884 http://dx.doi.org/10.1038/srep10832 |