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Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage

The tumor suppressor p53 has been studied extensively as a direct transcriptional activator of protein-coding genes. Recent studies, however, have shed light on novel regulatory functions of p53 within noncoding regions of the genome. Here, we use a systematic approach that integrates transcriptome-...

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Detalles Bibliográficos
Autores principales:	Younger, Scott T., Kenzelmann-Broz, Daniela, Jung, Heiyoun, Attardi, Laura D., Rinn, John L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482066/ https://www.ncbi.nlm.nih.gov/pubmed/25883152 http://dx.doi.org/10.1093/nar/gkv284

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