Cargando…

Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage

The tumor suppressor p53 has been studied extensively as a direct transcriptional activator of protein-coding genes. Recent studies, however, have shed light on novel regulatory functions of p53 within noncoding regions of the genome. Here, we use a systematic approach that integrates transcriptome-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Younger, Scott T., Kenzelmann-Broz, Daniela, Jung, Heiyoun, Attardi, Laura D., Rinn, John L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482066/ https://www.ncbi.nlm.nih.gov/pubmed/25883152 http://dx.doi.org/10.1093/nar/gkv284

Ejemplares similares

p53 regulates enhancer accessibility and activity in response to DNA damage
por: Younger, Scott T., et al.
Publicado: (2017)

KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage
por: Castellini, Laura, et al.
Publicado: (2017)

Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells
por: Akdemir, Kadir C., et al.
Publicado: (2014)

Heat shock factor-1 modulates p53 activity in the transcriptional response to DNA damage
por: Logan, Ian R., et al.
Publicado: (2009)

DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling
por: Banerjee, Taraswi, et al.
Publicado: (2009)

Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage
por: Wilson, Peter M., et al.
Publicado: (2009)

Transcription start site analysis reveals widespread divergent transcription in D. melanogaster and core promoter-encoded enhancer activities
por: Rennie, Sarah, et al.
Publicado: (2018)

A ChIP–chip approach reveals a novel role for transcription factor IRF1 in the DNA damage response
por: Frontini, Mattia, et al.
Publicado: (2009)

The Drosophila telomere-capping protein Verrocchio binds single-stranded DNA and protects telomeres from DNA damage response
por: Cicconi, Alessandro, et al.
Publicado: (2017)

Widespread repression of anti-CRISPR production by anti-CRISPR-associated proteins
por: Shehreen, Saadlee, et al.
Publicado: (2022)

Two p53 tetramers bind one consensus DNA response element
por: Kearns, Sinéad, et al.
Publicado: (2016)

An autonomous chromatin/DNA-PK mechanism for localized DNA damage signaling in mammalian cells
por: Muñoz, Denise P., et al.
Publicado: (2013)

A novel bipartite antitermination system widespread in conjugative elements of Gram-positive bacteria
por: Miguel-Arribas, Andrés, et al.
Publicado: (2021)

Gcn5-mediated Rph1 acetylation regulates its autophagic degradation under DNA damage stress
por: Li, Feng, et al.
Publicado: (2017)

AKT phosphorylates H3-threonine 45 to facilitate termination of gene transcription in response to DNA damage
por: Lee, Jong-Hyuk, et al.
Publicado: (2015)

Nucleosomes effectively shield DNA from radiation damage in living cells
por: Brambilla, Francesca, et al.
Publicado: (2020)

Integrative genomic analysis of human ribosomal DNA
por: Zentner, Gabriel E., et al.
Publicado: (2011)

Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress
por: McDade, Simon S., et al.
Publicado: (2014)

Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor
por: Neault, Mathieu, et al.
Publicado: (2012)

Widespread enhancer activation via ERα mediates estrogen response in vivo during uterine development
por: Jefferson, Wendy N, et al.
Publicado: (2018)

Widespread roles for piRNAs and WAGO-class siRNAs in shaping the germline transcriptome of Caenorhabditis elegans
por: Reed, Kailee J, et al.
Publicado: (2020)

In vivo methylation of mtDNA reveals the dynamics of protein–mtDNA interactions
por: Rebelo, Adriana P., et al.
Publicado: (2009)

Optimisation of TP53 reporters by systematic dissection of synthetic TP53 response elements
por: Trauernicht, Max, et al.
Publicado: (2023)

Genome-wide profiles of H2AX and γ-H2AX differentiate endogenous and exogenous DNA damage hotspots in human cells
por: Seo, Jungmin, et al.
Publicado: (2012)

p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells
por: Periyasamy, Manikandan, et al.
Publicado: (2017)

A transcriptional factor B paralog functions as an activator to DNA damage-responsive expression in archaea
por: Feng, Xu, et al.
Publicado: (2018)

Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation
por: Chen, Ruibing, et al.
Publicado: (2017)

Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters
por: Loughery, Jayne, et al.
Publicado: (2014)

Integrated multi-omics approach revealed cellular senescence landscape
por: Song, Qiao, et al.
Publicado: (2022)

CpG methylation potentiates pixantrone and doxorubicin-induced DNA damage and is a marker of drug sensitivity
por: Evison, Benny J., et al.
Publicado: (2009)

Human CHD1 is required for early DNA-damage signaling and is uniquely regulated by its N terminus
por: Zhou, Jia, et al.
Publicado: (2018)

Inhibition of p53 acetylation by INHAT subunit SET/TAF-Iβ represses p53 activity
por: Kim, Ji-Young, et al.
Publicado: (2012)

Two-step interrogation then recognition of DNA binding site by Integration Host Factor: an architectural DNA-bending protein
por: Velmurugu, Yogambigai, et al.
Publicado: (2018)

Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance
por: Vaughan, Robert M, et al.
Publicado: (2018)

Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents
por: Zhang, Pei-Ying, et al.
Publicado: (2016)

The complex architecture of p53 binding sites
por: Senitzki, Alon, et al.
Publicado: (2021)

Formation of stress-specific p53 binding patterns is influenced by chromatin but not by modulation of p53 binding affinity to response elements(†)
por: Millau, Jean-François, et al.
Publicado: (2011)

The nuclear mitotic apparatus protein NuMA controls rDNA transcription and mediates the nucleolar stress response in a p53-independent manner
por: Jayaraman, Swaathi, et al.
Publicado: (2017)

Retrograde BMP signaling activates neuronal gene expression through widespread deployment of a conserved BMP-responsive cis-regulatory activation element
por: Vuilleumier, Robin, et al.
Publicado: (2019)

Transcriptional network dynamics during the progression of pluripotency revealed by integrative statistical learning
por: Kim, Hani Jieun, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_pgoag4h37l4a1do4v3hvtv9lhc