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CWC22-dependent pre-mRNA splicing and eIF4A3 binding enables global deposition of exon junction complexes

In metazoan cells, spliced mRNAs are marked by the exon junction complex (EJC), a multi-protein complex that serves as a key regulator of post-transcriptional mRNA metabolism. Deposition of EJCs on mRNA is intimately linked to the splicing process. The spliceosomal protein CWC22 directly binds the c...

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Detalles Bibliográficos
Autores principales:	Steckelberg, Anna-Lena, Altmueller, Janine, Dieterich, Christoph, Gehring, Niels H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482076/ https://www.ncbi.nlm.nih.gov/pubmed/25870412 http://dx.doi.org/10.1093/nar/gkv320

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