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Functional interplay between the RK motif and linker segment dictates Oct4–DNA recognition

The POU family transcription factor Oct4 plays pivotal roles in regulating pluripotency and somatic cell reprogramming. Previous studies have indicated an important role for major groove contacts in Oct4–DNA recognition; however, the contributions of the RK motif in the POUh domain and the linker se...

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Detalles Bibliográficos
Autores principales:	Kong, Xiangqian, Liu, Jian, Li, Lianchun, Yue, Liyan, Zhang, Lihong, Jiang, Hualiang, Xie, Xin, Luo, Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Computational Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482079/ https://www.ncbi.nlm.nih.gov/pubmed/25870414 http://dx.doi.org/10.1093/nar/gkv323

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