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Structure–Function Analysis of the Non-Muscle Myosin Light Chain Kinase (nmMLCK) Isoform by NMR Spectroscopy and Molecular Modeling: Influence of MYLK Variants

The MYLK gene encodes the multifunctional enzyme, myosin light chain kinase (MLCK), involved in isoform-specific non-muscle and smooth muscle contraction and regulation of vascular permeability during inflammation. Three MYLK SNPs (P21H, S147P, V261A) alter the N-terminal amino acid sequence of the...

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Detalles Bibliográficos
Autores principales:	Shen, Kui, Ramirez, Benjamin, Mapes, Brandon, Shen, Grace R., Gokhale, Vijay, Brown, Mary E., Santarsiero, Bernard, Ishii, Yoshitaka, Dudek, Steven M., Wang, Ting, Garcia, Joe G. N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482139/ https://www.ncbi.nlm.nih.gov/pubmed/26111161 http://dx.doi.org/10.1371/journal.pone.0130515

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