Tumor-Targeted Human T Cells Expressing CD28-Based Chimeric Antigen Receptors Circumvent CTLA-4 Inhibition

Adoptive T cell therapy represents a promising treatment for cancer. Human T cells engineered to express a chimeric antigen receptor (CAR) recognize and kill tumor cells in a MHC-unrestricted manner and persist in vivo when the CAR includes a CD28 costimulatory domain. However, the intensity of the...

Descripción completa

Detalles Bibliográficos
Autores principales: Condomines, Maud, Arnason, Jon, Benjamin, Reuben, Gunset, Gertrude, Plotkin, Jason, Sadelain, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482147/
https://www.ncbi.nlm.nih.gov/pubmed/26110267
http://dx.doi.org/10.1371/journal.pone.0130518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482147/
https://www.ncbi.nlm.nih.gov/pubmed/26110267
http://dx.doi.org/10.1371/journal.pone.0130518

Ejemplares similares