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Tumor-Targeted Human T Cells Expressing CD28-Based Chimeric Antigen Receptors Circumvent CTLA-4 Inhibition

Adoptive T cell therapy represents a promising treatment for cancer. Human T cells engineered to express a chimeric antigen receptor (CAR) recognize and kill tumor cells in a MHC-unrestricted manner and persist in vivo when the CAR includes a CD28 costimulatory domain. However, the intensity of the...

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Detalles Bibliográficos
Autores principales:	Condomines, Maud, Arnason, Jon, Benjamin, Reuben, Gunset, Gertrude, Plotkin, Jason, Sadelain, Michel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482147/ https://www.ncbi.nlm.nih.gov/pubmed/26110267 http://dx.doi.org/10.1371/journal.pone.0130518

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