Detection of Peramivir and Laninamivir, New Anti-Influenza Drugs, in Sewage Effluent and River Waters in Japan

This is the first report of the detection of two new anti-influenza drugs, peramivir (PER) and laninamivir (LAN), in Japanese sewage effluent and river waters. Over about 1 year from October 2013 to July 2014, including the influenza prevalence season in January and February 2014, we monitored for f...

Descripción completa

Detalles Bibliográficos
Autores principales: Azuma, Takashi, Ishiuchi, Hirotaka, Inoyama, Tomomi, Teranishi, Yusuke, Yamaoka, Misato, Sato, Takaji, Yamashita, Naoyuki, Tanaka, Hiroaki, Mino, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482326/
https://www.ncbi.nlm.nih.gov/pubmed/26110817
http://dx.doi.org/10.1371/journal.pone.0131412
_version_ 1782378423571709952
author Azuma, Takashi
Ishiuchi, Hirotaka
Inoyama, Tomomi
Teranishi, Yusuke
Yamaoka, Misato
Sato, Takaji
Yamashita, Naoyuki
Tanaka, Hiroaki
Mino, Yoshiki
author_facet Azuma, Takashi
Ishiuchi, Hirotaka
Inoyama, Tomomi
Teranishi, Yusuke
Yamaoka, Misato
Sato, Takaji
Yamashita, Naoyuki
Tanaka, Hiroaki
Mino, Yoshiki
author_sort Azuma, Takashi
collection PubMed
description This is the first report of the detection of two new anti-influenza drugs, peramivir (PER) and laninamivir (LAN), in Japanese sewage effluent and river waters. Over about 1 year from October 2013 to July 2014, including the influenza prevalence season in January and February 2014, we monitored for five anti-influenza drugs—oseltamivir (OS), oseltamivir carboxylate (OC), zanamivir (ZAN), PER, and LAN—in river waters and in sewage effluent flowing into urban rivers of the Yodo River system in Japan. The dynamic profiles of these anti-influenza drugs were synchronized well with that of the numbers of influenza patients treated with the drugs. The highest levels in sewage effluents and river waters were, respectively, 82 and 41 ng/L (OS), 347 and 125 ng/L (OC), 110 and 35 ng/L (ZAN), 64 and 11 ng/L (PER), and 21 and 9 ng/L (LAN). However, application of ozone treatment before discharge from sewage treatment plants was effective in reducing the levels of these anti-influenza drugs in effluent. The effectiveness of the ozone treatment and the drug dependent difference in susceptibility against ozone were further evidenced by ozonation of a STP effluent in a batch reactor. These findings should help to promote further environmental risk assessment of the generation of drug-resistant influenza viruses in aquatic environments.
format Online
Article
Text
id pubmed-4482326
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-44823262015-07-01 Detection of Peramivir and Laninamivir, New Anti-Influenza Drugs, in Sewage Effluent and River Waters in Japan Azuma, Takashi Ishiuchi, Hirotaka Inoyama, Tomomi Teranishi, Yusuke Yamaoka, Misato Sato, Takaji Yamashita, Naoyuki Tanaka, Hiroaki Mino, Yoshiki PLoS One Research Article This is the first report of the detection of two new anti-influenza drugs, peramivir (PER) and laninamivir (LAN), in Japanese sewage effluent and river waters. Over about 1 year from October 2013 to July 2014, including the influenza prevalence season in January and February 2014, we monitored for five anti-influenza drugs—oseltamivir (OS), oseltamivir carboxylate (OC), zanamivir (ZAN), PER, and LAN—in river waters and in sewage effluent flowing into urban rivers of the Yodo River system in Japan. The dynamic profiles of these anti-influenza drugs were synchronized well with that of the numbers of influenza patients treated with the drugs. The highest levels in sewage effluents and river waters were, respectively, 82 and 41 ng/L (OS), 347 and 125 ng/L (OC), 110 and 35 ng/L (ZAN), 64 and 11 ng/L (PER), and 21 and 9 ng/L (LAN). However, application of ozone treatment before discharge from sewage treatment plants was effective in reducing the levels of these anti-influenza drugs in effluent. The effectiveness of the ozone treatment and the drug dependent difference in susceptibility against ozone were further evidenced by ozonation of a STP effluent in a batch reactor. These findings should help to promote further environmental risk assessment of the generation of drug-resistant influenza viruses in aquatic environments. Public Library of Science 2015-06-25 /pmc/articles/PMC4482326/ /pubmed/26110817 http://dx.doi.org/10.1371/journal.pone.0131412 Text en © 2015 Azuma et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Azuma, Takashi
Ishiuchi, Hirotaka
Inoyama, Tomomi
Teranishi, Yusuke
Yamaoka, Misato
Sato, Takaji
Yamashita, Naoyuki
Tanaka, Hiroaki
Mino, Yoshiki
Detection of Peramivir and Laninamivir, New Anti-Influenza Drugs, in Sewage Effluent and River Waters in Japan
title Detection of Peramivir and Laninamivir, New Anti-Influenza Drugs, in Sewage Effluent and River Waters in Japan
title_full Detection of Peramivir and Laninamivir, New Anti-Influenza Drugs, in Sewage Effluent and River Waters in Japan
title_fullStr Detection of Peramivir and Laninamivir, New Anti-Influenza Drugs, in Sewage Effluent and River Waters in Japan
title_full_unstemmed Detection of Peramivir and Laninamivir, New Anti-Influenza Drugs, in Sewage Effluent and River Waters in Japan
title_short Detection of Peramivir and Laninamivir, New Anti-Influenza Drugs, in Sewage Effluent and River Waters in Japan
title_sort detection of peramivir and laninamivir, new anti-influenza drugs, in sewage effluent and river waters in japan
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482326/
https://www.ncbi.nlm.nih.gov/pubmed/26110817
http://dx.doi.org/10.1371/journal.pone.0131412
work_keys_str_mv AT azumatakashi detectionofperamivirandlaninamivirnewantiinfluenzadrugsinsewageeffluentandriverwatersinjapan
AT ishiuchihirotaka detectionofperamivirandlaninamivirnewantiinfluenzadrugsinsewageeffluentandriverwatersinjapan
AT inoyamatomomi detectionofperamivirandlaninamivirnewantiinfluenzadrugsinsewageeffluentandriverwatersinjapan
AT teranishiyusuke detectionofperamivirandlaninamivirnewantiinfluenzadrugsinsewageeffluentandriverwatersinjapan
AT yamaokamisato detectionofperamivirandlaninamivirnewantiinfluenzadrugsinsewageeffluentandriverwatersinjapan
AT satotakaji detectionofperamivirandlaninamivirnewantiinfluenzadrugsinsewageeffluentandriverwatersinjapan
AT yamashitanaoyuki detectionofperamivirandlaninamivirnewantiinfluenzadrugsinsewageeffluentandriverwatersinjapan
AT tanakahiroaki detectionofperamivirandlaninamivirnewantiinfluenzadrugsinsewageeffluentandriverwatersinjapan
AT minoyoshiki detectionofperamivirandlaninamivirnewantiinfluenzadrugsinsewageeffluentandriverwatersinjapan