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Computational Modelling of NF-κB Activation by IL-1RI and Its Co-Receptor TILRR, Predicts a Role for Cytoskeletal Sequestration of IκBα in Inflammatory Signalling

The transcription factor NF-κB (nuclear factor kappa B) is activated by Toll-like receptors and controlled by mechanotransduction and changes in the cytoskeleton. In this study we combine 3-D predictive protein modelling and in vitro experiments with in silico simulations to determine the role of th...

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Detalles Bibliográficos
Autores principales:	Rhodes, David M., Smith, Sarah A., Holcombe, Mike, Qwarnstrom, Eva E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482363/ https://www.ncbi.nlm.nih.gov/pubmed/26110282 http://dx.doi.org/10.1371/journal.pone.0129888

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