Let-7 miRNAs Modulate the Activation of NF-κB by Targeting TNFAIP3 and Are Involved in the Pathogenesis of Lupus Nephritis

TNFAIP3 is a ubiquitin-editing enzyme that negatively regulates multiple NF-κB signaling pathways and dysregulation of TNFAIP3 is related to systemic lupus erythematosus (SLE). Although there exists evidence indicating that microRNAs (miRNAs) modulate the expression of TNFAIP3, whether and how miRNA...

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Detalles Bibliográficos
Autores principales: Liu, Jun, Zhu, Lin, Xie, Guang-liang, Bao, Jing-fang, Yu, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482407/
https://www.ncbi.nlm.nih.gov/pubmed/26110642
http://dx.doi.org/10.1371/journal.pone.0121256

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