ABC Transporters and the Proteasome Complex Are Implicated in Susceptibility to Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis across Multiple Drugs

Stevens–Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) represent rare but serious adverse drug reactions (ADRs). Both are characterized by distinctive blistering lesions and significant mortality rates. While there is evidence for strong drug-specific genetic predisposition related to H...

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Detalles Bibliográficos
Autores principales: Nicoletti, Paola, Bansal, Mukesh, Lefebvre, Celine, Guarnieri, Paolo, Shen, Yufeng, Pe’er, Itsik, Califano, Andrea, Floratos, Aris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482486/
https://www.ncbi.nlm.nih.gov/pubmed/26110827
http://dx.doi.org/10.1371/journal.pone.0131038

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