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The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin
Thrombin is a serine protease of the chymotrypsin family that acts both as a procoagulant and as an anticoagulant by cleaving either factor VIII, factor V and fibrinogen or protein C, respectively. Numerous previous studies have shown that electropositive regions at a distance from the active site,...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482499/ https://www.ncbi.nlm.nih.gov/pubmed/26110612 http://dx.doi.org/10.1371/journal.pone.0129511 |