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The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin

Thrombin is a serine protease of the chymotrypsin family that acts both as a procoagulant and as an anticoagulant by cleaving either factor VIII, factor V and fibrinogen or protein C, respectively. Numerous previous studies have shown that electropositive regions at a distance from the active site,...

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Detalles Bibliográficos
Autores principales:	Chahal, Gurdeep, Thorpe, Michael, Hellman, Lars
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482499/ https://www.ncbi.nlm.nih.gov/pubmed/26110612 http://dx.doi.org/10.1371/journal.pone.0129511

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