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Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint

RhoH, an atypical small Rho-family GTPase, critically regulates thymocyte differentiation through the coordinated interaction with Lck and Zap70. Therefore, RhoH deficiency causes defective T cell development, leading to a paucity of mature T cells. Since there has been no gain-of-function study on...

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Detalles Bibliográficos
Autores principales:	Tamehiro, Norimasa, Oda, Hiroyo, Shirai, Mutsunori, Suzuki, Harumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482576/ https://www.ncbi.nlm.nih.gov/pubmed/26114424 http://dx.doi.org/10.1371/journal.pone.0131047

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