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Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration

HIV Nef acts as an anti-autophagic maturation factor through interaction with beclin-1 (BECN1). We report that exposure of macrophages to infectious or non-infectious purified HIV induces toll-like receptor 8 (TLR8) and BECN1 dependent dephosphorylation and nuclear translocation of TFEB and that thi...

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Detalles Bibliográficos
Autores principales:	Campbell, Grant R., Rawat, Pratima, Bruckman, Rachel S., Spector, Stephen A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482621/ https://www.ncbi.nlm.nih.gov/pubmed/26115100 http://dx.doi.org/10.1371/journal.ppat.1005018

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